A new variant of the selective-repeat protocol is presented. While the protocols used until now have been based on cumulative acknowledgments and a single retransmit timer, a protocol based on individual acknowledgments and a separate timer for each outstanding packet is proposed here. In spite of a slightly increased complexity of the proposed protocol, when comparing it to the basic selective...

We investigate the error versus reject tradeo for classi ers. Our analysis is motivated by the remarkable similarity in error-reject tradeo curves for widely di ering algorithms classifying handwritten characters. We present the data in a new scaled version that makes this universal character particularly evident. Based on Chow's theory of the error-reject tradeo and its underlying Bayesian ana...

The TIM (T cell immunoglobulin mucin) proteins have emerged as key regulators of allergic and autoimmune diseases due to their influence on T helper (Th)-1 and Th-2 responses. On page 955, Chen and colleagues show that one member of this family, TIM-2, multitasks as a receptor for H-ferritin, a component of the iron storage protein ferritin. Ferritin was not what the group expected to find when...

A protein known for its role in dismantling faulty SNARE complexes can also help to maintain complexes that have formed properly during membrane fusion.

We consider the problem of preemptively scheduling a set of n jobs on m (identical, uniformly related, or unrelated) parallel machines. The scheduler may reject a subset of the jobs and thereby incur jobdependent penalties for each rejected job, and he must construct a schedule for the remaining jobs so as to optimize the preemptive makespan on the m machines plus the sum of the penalties of th...

The -level Uncapacitated Facility Location (UFL) problem is a generalization of the UFL and the -median problems. A significant shortcoming of the classical UFL problem is that often a few very distant customers, known as outliers, can leave an undesirable effect on the final solution. This deficiency is considered in a new variant called UFL with outliers, in which, in contrast to the other pr...