1. To develop a state-of-the-art ocean 4-dimensional variational (4D-Var) data assimilation and ocean forecasting system for the Regional Ocean Modeling System (ROMS); 2. To develop a state-of-the-art suite of post-processing and diagnostic tools in support of ROMS 4D-Var; 3. To gain the necessary experience using the ROMS 4D-Var systems in complex circulation environments; 4. To train the next...

Exercise [2.1.5] Let > 0 and pick K = K( ) finite such that if k ≥ K then r(k) ≤ . Applying the Cauchy-Schwarz inequality for Xi −EXi and Xj −EXj we have that Cov(Xi, Xj) ≤ [Var(Xi)Var(Xj)] ≤ r(0) <∞ for all i, j. Thus, breaking the double sum in Var(Sn) = ∑n i,j=1 Cov(Xi, Xj) into {(i, j) : |i − j| < K} and {(i, j) : |i− j| ≥ K} gives the bound Var(Sn) ≤ 2Knr(0) + n . Dividing by n we see that...

Exercise [2.1.5] Let > 0 and pick K = K( ) finite such that if k ≥ K then r(k) ≤ . Applying the Cauchy-Schwarz inequality for Xi −EXi and Xj −EXj we have that Cov(Xi, Xj) ≤ [Var(Xi)Var(Xj)] ≤ r(0) <∞ for all i, j. Thus, breaking the double sum in Var(Sn) = ∑n i,j=1 Cov(Xi, Xj) into {(i, j) : |i − j| < K} and {(i, j) : |i− j| ≥ K} gives the bound Var(Sn) ≤ 2Knr(0) + n . Dividing by n we see that...

DNA/RNA Description TRPV1 gene consists of 17 exons and 17 introns including a coding region and a 5' and a 3' non-coding region. Transcription There are four transcript variants encoding the same protein, but with different segments in the 5' UTR (var.1, var.2, var.3, var.4) and one alternative splice variant lacking exon 7 (TRPV1b). TRPV1 gene transcription was demonstrated in different cells...

Cryptococcus neoformans var. neoformans (74 isolates) and C. neoformans var. gattii (44 isolates) were used to test urease activity after growth on both yeast extract-glucose-peptone agar (YEPG) and on YEPG supplemented with 100 microM EDTA. Every isolate grown on YEPG agar for 48 h at 30 degrees C produced a positive reaction within 1 h in a modified rapid urease assay at 37 degrees C. However...

The formulation of the National Centers for Environmental Prediction four-dimensional variational dataassimilation (4D-Var) system is described. Results of applying 4D-Var over a one-week assimilation period, with a full set of physical parametrizations, are presented and compared with those of 3D-Var. The linearization has been performed without simplifications and, therefore, the tangent-line...

The antimicrobial activity of three different extracts (hexanic, ethyl acetate, methanol) obtained from Brazilian Drosera species (D. communis, D. montana var. montana, D. brevifolia, D. villosa var. graomogolensis, D. villosa var. villosa, Drosera sp. 1, and Drosera sp. 2 ) were tested against Staphylococcus aureus (ATCC 25923), Enterococcus faecium (ATCC23212), Pseudomonas aeruginosa (ATCC278...

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by approximately 60 var genes per haploid genome. Most var genes are grouped into 3 subgroups: A, B, and C. Evidence is emerging that the specific expression of these subgroups has clinical significance. Using field samples from child...

It has recently been demonstrated that activity of the essential JIL-1 histone H3S10 kinase is a major regulator of chromatin structure and that it functions to maintain euchromatic domains while counteracting heterochromatization and gene silencing. In the absence of JIL-1 kinase activity, the major heterochromatin markers histone H3K9me2 and HP1 spread in tandem to ectopic locations on the ch...