Acquired hypothyroidism is one of the most common endocrine disorders in the childhood, but long-term problems are observed in rare untreated patients. Van Wyk-Grumbach syndrome which is one of these problems was described as juvenile hypothyroidism, delayed bone age and isosexual early puberty in 1960 for the first time (1). This condition is mostly manifested with ovarian cysts, early menstru...

Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, isosexual precocious puberty and massive ovarian cysts. We report such a case in a 7-yearold girl who presented with a bilateral pelvic pain, abdominal distension and signs of hypothyroidism. Physical examination showed a breast development and lack of pubic and axillary hair. There was no clitoromeg...

Hypothyroidism can cause significant reproductive morbidity and its association with ovarian cyst formation is rare when it occurs in children, referred to as Van Wyk Grumbach syndrome. An 18-year-old girl was our emergency services suspicion of torsion USG findings she had pain abdomen vomiting 3 days duration. She provisionally prepared for laparoscopic surgery but on revaluation by bilateral...