sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

The effects of alpha-ketoglutarate (alpha-KG) on sodium valproate-induced hyperammonemia and hepatotoxicity were studied in biochemical experiments in rats. The levels of ammonia, urea, serum transaminases, hydroperoxides and thiobarbituric acid reactive substances were significantly increased in sodium valproate-treated rats. These levels were significantly decreased in alpha-KG- and sodium va...

abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

Targeting epigenetic changes in diffuse intrinsic pontine glioma (DIPG) may provide a novel treatment option for patients. This report demonstrates that sodium valproate, a histone deacetylase inhibitor (HDACi), can increase the cytotoxicity of carboplatin in an additive and synergistic manner in DIPG cells in vitro. Sodium valproate causes a dose-dependent decrease in DIPG cell viability in th...

OBJECTIVE To investigate the target cells and molecules with sodium valproate induced differentiation of human glioma cells. METHODS Nude mice bearing human glioma xenogenic graft subcutaneously were treated with sodium valproate. The expressions of HDAC1 and Tob genes of xenografts were analyzed with semiquantitative RT-PCR. The CD133+ cells (BTSCs) were isolated from glioma specimens by imm...

As the brand Epilim, there is a sugar free liquid and oral syrup both containing sodium valproate 200mg in 5ml. It is also available as sodium valproate 100mg crushable tablets, 200mg and 500mg enteric coated tablets and 200mg, 300mg and 500mg modified release tablets. There are also a number of these preparations available as generic formulations both of sodium valproate and valproic acid. It ...

A 34-year-old woman presented with a 3-day history of dyspnea. She denied any preceding fever, night sweats, cough, pleurisy, or coryzal symptoms. was maintained on sodium valproate 800 mg b.i.d., phenytoin 100 o.d., folate 5 and clonazepam 2 nocte for known seizure disorder. Clinical examination radiologic imaging revealed large left-sided pleural effusion the associated collapse left lower lu...

OBJECTIVE Migraine headache is a chronic and disabling condition in adults. Some studies have investigated the efficacy of sodium valproate in the treatment of acute migraine, but the effectiveness and tolerability of intravenous valproate as abortive therapy remains unclear. This study aimed to evaluate the effects of sodium valproate and dexamethasone in the treatment of acute migraine. MET...

Background: Sodium valproate, an anticonvulsant drug, is reported to stimulate Human Immunodeficiency Virus type 1 and Human cytomegalovirus replication. Since epileptic patients undergoing sodium valproate therapy may suffer from various virus infections, the effect of this drug on replication of viruses especially those affecting neuronal tissues such as Herpes simplex virus type 1 is worthy ...