Central venous catheter dysfunction is a frequent problem and often is defined as a blood flow <300 ml/min. This prospective, cross-sectional study included 259 patients and examined the relationship between catheter blood flow and dialysis adequacy as measured by urea reduction ratio (URR), single pool urea kinetics, and online effective ionic dialysance clearance. Dialysis adequacy at blood f...

Low dose of hemodialysis (HD) and small body size are independent risk factors for mortality. Recent changes in clinical practice, toward higher HD doses and use of more high-flux dialyzers, suggest the need to redetermine the dose level above which no benefit from higher dose can be observed. Data were analyzed from 45,967 HD patients starting end-stage renal disease (ESRD) therapy during Apri...

The prostanoid prostacyclin plays a central role in haemostasis and vascular repair. Recent studies investigating the regulation of the human prostacyclin receptor (hIP) gene identified an upstream repressor region (URR) within its regulatory promoter, herein termed the PrmIP. This study aimed to identify the main trans-acting factors that bind within the URR to transcriptionally repress PrmIP-...

Monte Carlo neutron transport codes can be used for high-fidelity predictions of the performance nuclear systems. However, validation against experiments is required in order to establish credibility results and identify inaccuracies due calculation scheme associated databases. The International Handbook Evaluated Criticality Safety Benchmark Experiments (ICSBEP) contains criticality safety ben...

Introduction: Food intake during hemodialysis (HD) is a controversial issue. The potential benefits include improvement of nutritional status and patient satisfaction. However, the risks possibility intradialytic hypotension (IDH) dialysis inadequacy. There are no guidelines regarding food HD. Objectives: To assess impact HD on IDH adequacy. Patients Methods: This was single-center quasi-experi...

To achieve its goal to be user-driven, building the Global Earth Observation System of Systems (GEOSS) must be guided by a set of explicitly known user needs. At the core of GEOSS is the GEOSS Common Infrastructure (GCI), which includes registries that enable users of Earth observations to search, discover, access, and use the data and services available through GEOSS. Three of these registries...

Using linker scanning mutational analysis, we recently identified potential cis regulatory elements contained within the 5' upstream regulatory region (URR) domain and auxiliary enhancer (AE) region of the human papillomavirus type 31 (HPV31) URR involved in the regulation of E6/E7 promoter activity at different stages of the viral life cycle. For the present study, we extended the linker scann...

A model capable of projecting mineral resources production has been developed. The model includes supply and demand interactions, and has been applied to all coal producing countries. A model of worldwide coal production has been developed for three scenarios. The ultimately recoverable resources (URR) estimates used in the scenarios ranged from 700 Gt to 1243 Gt. The model indicates that world...

Statistical literature has several methods for coping with multicollinearity. This paper introduces a new shrinkage estimator, called modified unbiased ridge (MUR). This estimator is obtained from unbiased ridge regression (URR) in the same way that ordinary ridge regression (ORR) is obtained from ordinary least squares (OLS). Properties of MUR are derived. Results on its matrix mean squared er...