In the Henderson-Hasselbalchequation,pH = pK + Iog(HCO/S#{149}pc02), the millirnolar partition coefficient, per mmHg pressure (S), and pK1 are considered to be constants.Combining these two constants gives pH = pK19 + log(HCO/po2). In this paper, we report the results of a study designed to test the constancy of pK19. This was done by varying the blood and urine pH in two patients by administra...

A 46-year-old female had a history of recurrent uric acid stone formation, but the reason why uric acid precipitated in her urine was not obvious, because the rate of urate excretion was not high, urine volume was not low, and the pH in her 24-h urine was not low enough. In his discussion of the case, Professor McCance provided new insights into the pathophysiology of uric acid stone formation....

BACKGROUND/AIMS A variety of risk factors for chronic kidney disease (CKD), including the metabolic syndrome, were recently reported. It has been suggested that a low urine pH is another characteristic of the metabolic syndrome. However, the relationship between urine pH and CKD remains to be elucidated. METHODS A cohort study was performed on 1,811 subjects who underwent a health check-up, a...

Urine pH was monitored on a large Midwest dairy, where 161 multiparous cows received CLOSE-UP PELLET as part of their pre-fresh ration (Technical Service Bulletin #308). Pre-calving urine pH among the 8 mature cows treated for milk fever averaged 7.51, while mean urine pH among the 153 other cows was 7.61. At 5.0%, the incidence rate of milk fever was low for multiparous cows. A typical milk fe...

Kill kinetics and MICs of finafloxacin and ciprofloxacin against 34 strains with defined resistance mechanisms grown in cation-adjusted Mueller-Hinton broth (CAMHB) at pH values of 7.2 and 5.8 and in synthetic urine at pH 5.8 were determined. In general, finafloxacin gained activity at low pH values in CAMHB and remained almost unchanged in artificial urine. Ciprofloxacin MICs increased and bac...

The Mandatory Guidelines for Federal Workplace Drug Testing Programs provide criteria for specimen validity testing, including urine pH cut-offs, to report a urine specimen as adulterated or invalid. Since the urine pH criteria for invalid classifications, > or = 3 and < 4.5 or > or = 9 and < 11, became effective in November 2004, a number of specimens with results within the upper invalid limi...

Human stone calcium phosphate (CaP) content correlates with higher urine CaP supersaturation (SS) and urine pH as well as with the number of shock wave lithotripsy (SWL) treatments. SWL does damage medullary collecting ducts and vasa recta, sites for urine pH regulation. We tested the hypothesis that SWL raises urine pH and therefore Cap SS, resulting in CaP nucleation and tubular plugging. The...

The pH of urine samples from patients suffering symptoms suggesting urinary infection (e.g. dysuria, frequency, urgency) was measured while the patients were symptomatic and again when they had become asymptomatic. There was no correlation between the urine pH and the incidence or number of symptoms. No differences were observed between either the distribution or means of urine pH values in sym...

Urinary excretion of f32-microglobulin (f2M) is a widely used test of renal proximal tubular function. /32M is known to be unstable in normal urine with a pH <5.5. The results of a study of /32M excretion in patients receiving gentamicin suggested that 32M might be more unstable in pathological urine. A series of experiments was designed to define the extent, variability, and mechanism of its i...

Analysis for calcium, magnesium, phosphorus, oxalate, uric acid, and creatinine in 24-h urine collections is often needed for the differential diagnosis of patients with renal calculi. Considerable attention has been given to improving the methods of analysis, but improper sample collection and processing can cause significant errors for calcium and oxalate in urine samples not treated with aci...