OBJECTIVE To determine the value of random urinary protein to creatinine ratio (UPCR) for diagnosis of proteinuria in pregnant women with preeclampsia. Preeclampsia is the most common complication of pregnancy and one of the main causes of maternal mortality. So, early diagnosis of preeclampsia is very important. MATERIALS AND METHODS In this cross-sectional study 66 pregnant women suspected ...

OBJECTIVE To measure the effects of increasing mean arterial pressure (MAP) on systemic oxygen metabolism and regional tissue perfusion in septic shock. DESIGN Prospective study. SETTING Medical and surgical intensive care units of a tertiary care teaching hospital. PATIENTS Ten patients with the diagnosis of septic shock who required pressor agents to maintain a MAP > or = 60 mm Hg after...

We congratulate Fathi et al. [1] for their effort to analyze the oncometabolite 2-hydroxyglutarate (2-HG).This is an interesting work evaluating 2-HG in serum, urine, and cerebrospinal fluid (CSF) from patients with isocitrate dehydrogenase (IDH) mutant and IDH wild-type (WT) glioma. The objective of this study was to use 2-HG as a surrogate biomarker for IDH mutation. Serum 2-HGwas found to be...

Background: The ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria.  Objective: We studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion. Methods: 150 children aged 0.11–17 years admitted to the Department of Pediatric Nephrology were included in this study. Early morning urine s...

BACKGROUND Toenail-Hg levels are being used as a marker of methylmercury (MeHg) exposure in efforts to associate exposure with effects such as cardiovascular disease. There is a need to correlate this marker with more established biomarkers that presently underlie existing dose-response relationships in order to compare these relationships across studies. METHODS As part of the Arsenic Mercur...

Certain gouty subjects with excessive de novo purine synthesis are deficient in hypoxanthineguanine phosphoribosyltransferase (HG-PRTase [EC 2.4.2.8]). The mechanism of accelerated uric acid formation in these patients was explored by measuring the incorporation of glycine-(14)C into various urinary purine bases of normal and enzyme-deficient subjects during treatment with the xanthine oxidase ...

In this communication, we molecularly engineered a light-switching excimer oligonucleotide-based probe for time-resolved fluorescent detection of Hg(2+). By combining a time-resolved fluorescence technique and magnetic nanoparticles, Hg(2+) spiked in human urine was detected.