OBJECTIVE We sought to test the effect of different dosages of pioglitazone (PIO) on the glomerular expression of podocalyxin and urinary sediment podocalyxin excretion and to explore the potential renoprotective mechanism. MATERIALS AND METHODS Type 1 diabetes induced with streptozotocin (65 mg/kg) in 36 male Sprague-Dawley rats were randomly allocated to be treated with vehicle or 10, 20, 3...

with 1 cell/HPF obtained with microscopy of the urinary sediment). Fewer epithelial cells and bacteria were seen in this population. In both groups, however, the values for erythrocytes and leukocytes varied, with ranges of ;1–36 cells/mL and ;3–57 cells/mL, respectively, when the results between the 5th and 95th percentile were examined. These values are obviously higher than those obtained wi...

Urinary sediment examination is an important diagnostic test for the diseases of the kidneys and of the urinary tract. EQAS on urinary sediment evaluation are very rare worldwide. The “Urinalysis Performance” managed by the Centre of Biomedical Research (CRB) an EQA scheme organization with many programs in different fields of Laboratory Medicine was established in 2001 by a promoting Committee...

BACKGROUND Acute kidney injury (AKI) is frequently observed in serious infections, following nephrotoxic medication, surgery and trauma. Here we tested whether the detection of two recently identified biomarkers for AKI, Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) and Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), depends on the expression of these proteins in cells of the urinary ...

BACKGROUND Identification and control of infections are important in the management of diabetic cats. Urinary tract infections have not been well characterized in diabetic cats. This retrospective study was performed to review and characterize urinary tract infections in diabetic cats. HYPOTHESIS Urinary tract infections are common in diabetic cats. ANIMALS A review was made of the medical ...

We evaluated the performance of automated-flow cytometry, urinalysis dipsticks and microscopic urine sediment analysis as predictors of urinary tract infection. Urine cultures were used as a reference method for comparison. Six-hundred-seventy-five urine samples from hospitalized and not hospitalized patients attended at Hospital Mãe de Deus, Porto Alegre, in south Brazil, were included in the ...

In the present issue of NDT, Chan et al. [1] report that the messenger (m) RNA expression of T-bet (a central Th1 transcription factor), interleukin (IL)-10, transforming growth factor (TGF)-b and MCP-1 in the urinary sediment of patients with active lupus nephritis decrease with successful immunosuppressive therapy. Importantly, various other cytokine mRNAs, including those of IL-2, -4, -12 an...

In this data article, by using inductively coupled plasma optical spectrometry (ICP-OES), we aimed to (1) determine the concentration levels of As, Ag, Sr, Sn, Sb, and Mo in the sediments and the shells of Trachycardium lacunosum simultaneously in two separated areas (unpolluted and polluted areas) (2) comparison between the metal contents of sediments in the unpolluted and polluted areas as we...

INTRODUCTION Loss of heterozygosity (LOH) is frequently observed in urinary bladder neoplasms. In the reported study, an attempt was undertaken to determine the loss of heterozygosity of TP53(17p13), RB1(13q14), CDKN2A/ ARF(9p21) genes in DNA from neoplastic tissue, collected from patients with diagnosed urinary bladder carcinoma, and to compare the results with those of LOH evaluation in DNA i...

Canine visceral leishmaniasis (CVL) is difficult to diagnosis, mainly due to the presence of asymptomatic animals, the diversity of clinical symptoms and the difficulty in obtaining diagnostic evidence of high sensitivity and specificity. The purpose of this study was to diagnose CVL in urinary sediment of 70 dogs of different breeds, sexes and ages from the veterinary hospital of the Federal U...