background classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of indicator genes in routine practice appears to be arduous. in a preceding published study, we utilized real-time pcr measurement of indicator genes in acute lymphoid leukaemia (all) and acute my...

The expression of tissue plasminogen activator (tPA) is increased during activity-dependent forms of synaptic plasticity. We have found that inhibitors of tPA inhibit the late phase of long-term potentiation (L-LTP) induced by either forskolin or tetanic stimulation in the hippocampal mossy fiber and Schaffer collateral pathways. Moreover, application of tPA enhances L-LTP induced by a single t...

There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts birds and mammals. Recent dangerous are MERS-CoV, SARS-CoV, SARS-CoV-2, causing illness even failure several organs. However, profound impact coronavirus on host cells remains elusive. In this study, we analyzed transcriptome SARS-CoV-2 infected human lung-derived cells, observed that infectio...

Upregulation of matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9 contributes to secondary pathogenesis of spinal cord injury (SCI) via promoting inflammation. Recently, we reported that trehalose suppresses inflammatory responses following SCI. Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI. A weight-drop contusion SCI was induced in male ...

Papillary renal cell carcinoma (pRCC) is an aggressive but minor type of RCC. The current understanding and management pRCC remain poor. We report here OIP5 being a novel oncogenic factor possessing robust prognostic values therapeutic potential. upregulation observed in pRCC. associated with adverse features (T1P < T2P CIMP, Stage1 + 2 Stage 3 4, N0 N1) effectively stratifies the fatality r...

Both the formation of long-term memory (LTM) and late-long-term potentiation (L-LTP), which is thought to represent the cellular model of learning and memory, require de novo protein synthesis. The mammalian target of Rapamycin (mTOR) complex I (mTORC1) integrates information from various synaptic inputs and its best characterized function is the regulation of translation. Although initial stud...

Using the nearest-neighbour STDP rule with metaplasticity we show that to evoke homosynaptic LTD or depotentiation in the spiking model of granule cell is not easy. This is in accordance with number of experimental studies. On the other hand, heterosynaptic LTD which accompanies homosynaptic LTP is induced readily both in the model as well as in experiments. We offer possible explanation of thi...