Amyloidosis cutis dyschromia is a rare form of primary cutaneous amyloidosis. Amyloid deposition in the skin occurs without systemic manifestations and produces hypopigmented and hyperpigmented macules. A 19-year-old woman is presented with progression of this condition over 16 years.

Amelanotic melanoma is an atypical that presents without pigmentation and can thus be misdiagnosed as benign neoplasm. Ungual trauma induce amelanotic of the fingernail well pyogenic granuloma (PG). We present case a patient in his 60s with PG-like lesion on third nail plate was preceded by ungual one year ago. A shave biopsy revealed ulcerated nodule composed epitheloid cells melanocytic atypi...

Thioglycolic acid (TA) and urea hydrogen peroxide (urea H(2)O(2)) are thought to disrupt alpha-keratin disulfide links in the nail. However, optimal clinical use of these agents to improve the treatment of nail disorders is currently hindered by a lack of fundamental data to support their mechanism of action. The aim of this study was to investigate how the redox environment of ungual keratin, ...

BACKGROUND The 2,790 nm Er:YSGG wavelength has a lower water absorption coefficient than the 2,940 nm Er:YAG, but a higher coefficient than the 10,600 nm CO(2) laser. This allows ablative resurfacing with mild thermal coagulation, which may increase clinical efficacy while reducing patient downtime. OBJECTIVES To evaluate the efficacy and safety of the confluent 2,790 nm Erbium:YSGG (Pearl™, ...

As part of an assessment for preeclampsia, a prenatal sonogram performed on a pregnant woman at 33 weeks 4 days' gestation showed ectrodactyly in all 4 fetal extremities. The woman's husband had a history of hand abnormalities but was unaware that his condition was genetic. His examination was notable for ectrodactyly, small, peg-shaped teeth, microretrognathia, nail dysplasia, and a history of...

Female, Hindoo, aged 40; not known to be hereditary; neither father nor mother, sisters, brothers, nor children, have the deformity. The thumb of the left hand was very broad, bulging out at the end of the first phalanx, and then narrowing to the root of the single normal nail. The metacarpal bone was single, but flattened at its distal extremity, and presented two articular surfaces, to which ...

Acral melanoma is a great pretender; anything but i nfrequently, it adopts clinical faces, simulating skin conditions that make the healthcare provider diagnose it as a benign disease of the palms, soles, and ungual regions. We present a case of a hyperkeratotic acral melanoma that has been misdiagnosed and that has led to an amputation of the thumb.