Sarcomas represent a challenge t clinicians as they are rare and diagnosis is often delayed. Soft tissue sarcomas are relatively uncommon cancers, the incidence is estimated about 1% from all malignant tumors. Due to aggressive biological behavior of pleomorphic undifferentiated sarcoma diagnosis must hi made as quickly as possible. MRI is the standard imaging modality for investigating possibl...

Malignant Fibrous Histiocytoma was historically the most commonly diagnosed soft tissue sarcoma of adults. In 2002, the World Health Organization declassified malignant fibrous histiocytoma as a formal diagnostic entity. They recommended renaming the disease "Pleomorphic Undifferentiated Sarcoma". Current thoughts about the origin of this tumor are being debated. We report a case of a dediffere...

BACKGROUND Primary and metastatic cardiac sarcomas represent a heterogeneous group of rare neoplasms with varying clinical course and diverse histogenetic line of differentiation. To date, there exist no uniform guidelines for their surgical and/or oncological treatment. METHODS We evaluated retrospectively all patients undergoing cardiac surgery for primary or secondary cardiac sarcoma in th...

AIMS Well-differentiated leiomyosarcomas show morphologically recognizable smooth muscle differentiation, whereas poorly differentiated tumours may form a spectrum with a subset of undifferentiated pleomorphic sarcomas. The expression of certain muscle markers has been reported to have prognostic impact. We investigated the correlation between the morphological spectrum and the muscle marker ex...

TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcomas demonstrate activation of YAP while 66% of sarcomas demonstrate activated TAZ. Differential act...

Undifferentiated high grade pleomorphic sarcoma is a deep seated pleomorphic soft tissue sarcoma of unknown pathogenesis. It typically occurs in the deep fascia and skeletal muscles of the extremities followed by the trunk and the head and neck. Chest wall is an uncommon site of origin. Chest wall tumors account for less than 1% of all tumors and are classified based on their tissue of origin. ...

With the exception of well-differentiated liposarcoma, dedifferentiated leiomyosarcoma, solitary fibrous tumour, malignant peripheral nerve sheath and undifferentiated pleomorphic sarcoma, majority ≈70 histologic subtypes retroperitoneal sarcoma are defined as ‘ultra-rare’ sarcomas, with an incidence ≤1–5/1,000,000 persons/year. For most these ultra-rare RPS subtypes, diagnosis treatment follow...

Undifferentiated pleomorphic sarcoma (UPS) is rare type of soft tissue sarcomas that occur in all parts body but mostly the extremities. Sixty-year-old woman presented dyspnea and stridor with benign looking subglottic mass on laryngoscope. Endoscopic laser surgery was performed histopathology showed diffuse proliferation plump spindle cells no particular orientation to vessels. In immunochemis...