نتایج جستجو برای: ultra low dose of morphine
تعداد نتایج: 21271499 فیلتر نتایج به سال:
background: usual dosage of morphine (10 mg/kg) induces analgesia and ultra-low dose (uld) of morphine (1 μg/kg); hyperalgesia, and c-fibers are also bearing μ- opioid receptors; here the importance of c-fibers on pain and morphine induced analgesia/hyperalgesia is questioned and investigated using pain evaluation methods and infant capsaicin treating for c-fibers lesioni...
Our previous electrophysiologic studies on nociceptive types of dorsal root ganglion (DRG) neurons in culture demonstrated that extremely low fM-nM concentrations of morphine and many other bimodally-acting mu, delta and kappa opioid agonists can elicit direct excitatory opioid receptor-mediated effects, whereas higher (microM) opioid concentrations evoked inhibitory effects. Cotreatment with p...
abstract the present study was conducted to examine the effect of proficiency on students interaction while carrying out the grammar-based task(s) in collaboration. in particular, the study examines whether the level of proficiency affects the learners’ focus of attention to grammatical and lexical features. the study takes a further step and examines whether there is any difference in the use...
Background and Objective: Opiates have complex effects on seizure activity. They have both anti- and proconvulsive effects depending on experimental conditions. The aim of this study was to determine the effects of different doses of morphine and naloxon on spontaneous seizure activity in mouse brain hippocampal slices. Materials and Methods: Spontaneous epileptic activity in the brain slices o...
Background: Renal colic is an acute flank pain which may radiate to the groin, lower abdomen, or external genitalia due to the passage of a urinary stones. Pain management is the most important task in emergency wards when a patient with renal colic attends. This study aims to compare intravenous acetaminophen plus a low dose of morphine with a full dose of morphine in renal colic. Methods: In ...
Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. Here we show that with approximately 200-fold higher affinity than for the mu opioid receptor, naloxone binds a ...
introduction: urine morphine test, in several countries is the most primarily available qualitative test for detecting opioid abusers. since the users of illicit drugs attempt to defeat urine tests and there are also plenty of claims that usage of hd (high dose) contraceptive pills can result in false-negative results, we decided to design the present study to investigate the probable in vitro ...
BACKGROUND/PURPOSE The addition of ultra-low-dose naloxone to patient-controlled analgesia (PCA) with morphine reduces opioid-related side effects. Nalbuphine, a mixed opioid agonist-antagonist, may be able to attenuate opioid-related side effects. The goal of the present study was to investigate the effect of combined low-dose nalbuphine and morphine in PCA for postoperative pain control after...
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