Non-cardioembolic stroke and transient ischemic attack (TIA) are heterogeneous conditions, some variants of which associated with a high short-term long-term risk cardiovascular events. The article presents clinical portraits patients in very groups: 1) extracranial atherosclerosis severe stenosis/subocclusion/occlusion or CT signs atherosclerotic plaque instability; 2) all intracranial atheros...

Considerable evidence supports that the CD4(+) T cell-mediated immune response contributes to the development of atherosclerotic plaque. However, the effects of Th17 cells on atherosclerosis are not thoroughly understood. In this study, we evaluated the production and function of Th17 and Th1 cells in atherosclerotic-susceptible ApoE(-/-) mice. We observed that the proportion of Th17 cells, as ...

A variety of imaging methods can be used in the diagnosis of atherosclerotic plaques. In the present study, we investigated the morphology and composition of atherosclerotic plaque associated with ischemic cerebral infarction by comparing gemstone spectral computed tomography (GSCT) and traditional multi-slice CT (MSCT). In total, 200 patients were enrolled and divided into the experimental gro...

The prevalence of atherosclerotic disease continues to increase, and despite significant reductions in major cardiovascular events with current medical interventions, an additional therapeutic window exists. Atherosclerotic plaque growth is a complex integration of cholesterol penetration, inflammatory cell infiltration, vascular smooth muscle cell (VSMC) migration, and neovascular invasion. A ...

Invasive angiography has been widely accepted as the gold standard to diagnose cardiovascular pathologies. Despite its superior resolution of demonstrating atherosclerotic plaque in terms of degree of lumen stenosis, the morphological assessment for the plaque is insufficient for the analysis of plaque components, and therefore, unable to predict the risk status or vulnerability of atherosclero...

Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermore, the pressure needed to inflate the plaque-covered balloon may be an index o...

OBJECTIVES To detect the correlation between high-sensitivity-CRP, carotid plaque, neurological function and intima-media thickness, and help physicians in the diagnosis of atherosclerotic cerebral infarction. METHODS A total of 96 patients with the first onset of atherosclerotic cerebral infarction were included in the study from July 2013 to May 2015. The test of high-sensitivity-CRP, exami...

Atherosclerotic plaque regression and HMG-CoA reductase inhibition potential of curcumin: An integrative omics in-vivo studyPriyanka Riyad, Ashok Purohit, Karishma Sen, Heera Ram

A 65-year-old man with a history of smoking, hypertension, and diabetes mellitus presented because of sudden-onset left hemiparesis. On admission, neurological examination disclosed a mild left-sided weakness, a normal consciousness level, and a right carotid bruit. The blood pressure, ECG, echocardiogram, and laboratory studies were all unremarkable. He was taking daily aspirin, enalapril, and...