The rapid development of biobanks internationally reflects the considerable expectations attached to the exploitation of genetics knowledge. However, establishing consent and legitimacy for the new generation of biobanks is not without its challenges because they tend to be prospective in nature, involving the collection of DNA, personal medical and lifestyle data generally held over a very lon...

w hether the united kingdom (uk) should remain in the european :union: (eu) or not has been a fiercely debated issue both before and after the referendum in the uk on june 23, 2016. the main purpose of this paper is to evaluate the pros and cons of the uk leaving the eu. it is concluded that if the uk leaves the eu, the resulting economic shock would risk adverse effects on macroeconomic variab...

introduction: the treatment of complicated parapneumonic effusion (ppe) and thoracic empyema (te) is controversial; and the choice of treatment after confirming the failure of simple drainage remains unclear. the purpose of this study was to compare the outcomes of intrapleural urokinase (uk) administration and video-assisted thoracoscopic surgery (vats) as initial treatment options for ppe and...

Together with M. Boyle and D. Huang (2000), this paper gives an alternate development of the Huang classification of shifts of finite type up to flow equivalence, and provides additional functorial information, used to analyze the action of the mapping class group of the mapping torus of a shift of finite type on the “isotopy futures” group, which is introduced here. For a shift of finite type ...

Our interest on engineering non-ribosomal synthetase responsible for SW-163 biosynthesis prompted us to determine the relative and absolute configuration of antitumor cyclic depsipeptide SW-163s. We first isolated and identified SW-163 homologs D, F and G as known compounds UK-63598, UK-65662 and UK-63052, respectively. Both enantiomers of the unusual constitutive amino acid, N-methylnorcoromic...

this is a commentary on gilbert and colleagues’ (1) paper on morality and markets in the national health service (nhs). morality and values are not ephemeral qualities and universal healthcare is not simply an aspiration; it has to be enshrined in law. the creation of the uk nhs in 1948 was underpinned by core legal duties which required a system of public funding and delivery to follow. the mo...