نتایج جستجو برای: ucp1 mrna

تعداد نتایج: 154080  

Journal: :Journal of lipid research 1999
M V Kumar G D Sunvold P J Scarpace

All-trans-retinoic acid (RA), an active metabolite of vitamin A, induces the gene expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and suppresses leptin gene expression in white adipose tissue (WAT) when given as an acute dose. These contrasting effects of RA leave in doubt the overall effect of chronic RA or vitamin A supplementation on energy homeostasis. To investigate...

Journal: :American journal of physiology. Endocrinology and metabolism 2001
S Viengchareun P Penfornis M C Zennaro M Lombès

Uncoupling proteins (UCP), specific mitochondrial proton transporters that function by uncoupling oxidative metabolism from ATP synthesis, are involved in thermoregulation and control of energy expenditure. The hibernoma-derived T37i cells, which possess functional endogenous mineralocorticoid receptors (MR), can undergo differentiation into brown adipocytes. In differentiated T37i cells, UCP1 ...

2016
Lev M Berstein Aglaya G Iyevleva Marina S Mukhina Dmitry A Vasilyev Tatyana E Poroshina

PURPOSE Adipose tissue products may contribute to endometrial cancer (EC) initiation and further growth that encourages the analysis of this issue in patients with different obesity phenotypes. METHODS/PATIENTS Omental fat depot characteristics were studied in EC patients (n = 57) with "standard" (SO) or "metabolically healthy" (MHO) obesity. Collected omental samples were evaluated by immuno...

Journal: :The Journal of veterinary medical science 2007
Naoya Kitao Takahiro Yahata Takaaki Matsumoto Yuko Okamatsu-Ogura Asako Omachi Kazuhiro Kimura Masayuki Saito

Uncoupling protein 1 (UCP1) is present exclusively in brown adipose tissue, and contributes to body temperature control during cold exposure. We cloned UCP1 cDNA of plateau pika (Ochotona dauurica), a small, non-hibernating, diurnal lagomorph that inhabits in relatively cold climates and at high altitudes in Mongolia and in northern China. The nucleotide sequence of pika UCP1 was highly homolog...

Journal: :Molecular and cellular biology 2005
Bingzhong Xue Ann Coulter Jong Seop Rim Robert A Koza Leslie P Kozak

Induction of brown adipocytes in white fat depots by adrenergic stimulation is a complex genetic trait in mice that affects the ability of the animal to regulate body weight. An 80-fold difference in expression of the mitochondrial uncoupling gene (Ucp1) at the mRNA and protein levels between A/J and C57BL/6J (B6) mice is controlled by allelic interactions among nine quantitative trait loci (QT...

Journal: :The Biochemical journal 2006
Irina G Shabalina Tatiana V Kramarova Jan Nedergaard Barbara Cannon

In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1-/- mice, fatty-acid-induced uncoupling exists. In the present investigation, we used the inhibitor CAtr (carboxyatractyloside) to examine the involvement of the ANT (adenine nucleotide translocator) in the mediation of this UCP...

2013

Background: The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1αdetermines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise trainingregulate UCP1 and PRDM16 expressio...

Journal: :Antiviral therapy 2003
Craig S Pace Annalise M Martin Emma L Hammond Cyril D Mamotte David A Nolan Simon A Mallal

OBJECTIVES To examine the in vivo effects of highly active antiretroviral therapy (HAART) regimens on adipose tissue mitochondrial DNA (mtDNA) depletion, mitochondrial organellar proliferation, and markers of adipocyte differentiation and phenotype. DESIGN AND METHODS DNA and mRNA quantification using real-time PCR methods was performed on adipose tissue samples from 31 HIV-infected individua...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2010
William T Festuccia Pierre-Gilles Blanchard Denis Richard Yves Deshaies

We investigated the involvement of basal sympathetic tone in brown adipose tissue (BAT) recruitment and gene expression profile induced by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation. Innervated and surgically denervated BAT pads of rats treated or not with rosiglitazone (15 mg.kg(-1).day(-1), 7 days) were evaluated for weight, triacylglycerol (TAG) and DNA content,...

Journal: :Molecular pharmacology 2013
Stephen M Kraynik Robert S Miyaoka Joseph A Beavo

Brown adipose tissue (BAT) is a highly thermogenic organ that converts lipids and glucose into heat. Many of the metabolic and gene transcriptional hallmarks of BAT activation, namely increased lipolysis, uncoupling protein-1 (UCP1) mRNA, and glucose uptake, are regulated by the adrenergic second messenger, cAMP. Cyclic nucleotide phosphodiesterases (PDEs) catalyze the breakdown of cAMP, thereb...

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