In vitro studies have shown phenolics in olive oil to be strong radical scavengers. The absorption and elimination of two radiolabeled phenolic constituents of olive oil, hydroxytyrosol and tyrosol were studied in vivo using rats. Compounds were administered intravenously (in saline) and orally (in oiland water-based solutions). For both compounds, the intravenously and orally administered oil-...

Oxidative stress plays a major role in ethanol-induced liver damage, and agents with antioxidant properties are promising as therapeutic opportunities in alcoholic liver disease. In the present work, we investigated the effect of S-adenosylmethionine (AdoMet), Tyrosol (Tyr), and their combination on HepG2 cells exposed to ethanol exploring the potential molecular mechanisms. We exposed HepG2 ce...

In this study, the effect of cultivar, harvest year, and geographic regions (Mediterranean, Aegean, Southeastern Anatolia, Marmara, Black Sea) on phenolic compounds virgin olive oils were investigated. Tyrosol was major compound in Mediterranean, Southeastern, Sea regions. Hydroxytyrosol showed highest value (2.07 mg/kg) Anatolia region lowest (0.75 Marmara region. Among acids, vanillic acid ha...

Active films made of chitosan and fish gelatin blends containing 5% (w/wt polymers) tyrosol, ferulic acid or caffeic were prepared by the casting method. The kinetic release was assessed in water 1% (w/v) NaCl solution, at three temperatures (4, 25 32°C). Partition (Kf/S) effective diffusivity (D) modelled which allowed to characterize mechanism. Tyrosol has a faster higher concentration than o...

Due to their excellent properties, clays have been widely used in several applications, particularly in catalysis. In this paper, three clays were used as heterogeneous photo-Fenton catalysts for phenol and tyrosol oxidations. Particular attention was given to the effect of the main operating conditions on the process performance. A total conversion was obtained for both organic pollutants with...

Abstract In this work, pilot-scale nanofiltration was used to obtain aqueous solutions rich in hydroxytyrosol and tyrosol from olive oil by-products. A large-scale simple process involving mill standard machinery (blender decanter) for the pomace pre-treatment with water. The extract then directly fed a unit concentrated by reverse osmosis. Final concentration factors ranged between 7 9 4 tyros...

Salidroside, a novel effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis A. Bor, can be derived from phenylalanine or tyrosine. Due to the scarcity of R. sachalinensis and its low yield of salidroside, there is great interest in enhancing production of salidroside by the plant. In this study, a cDNA clone encoding phenylalanine ammonia-lyase (PAL) was isolated f...

in this research, the quality indices, phenolic compounds (hydroxy tyrosol, tyrosol, cinamic and vanilic acid), fatty acids and pigments from olive oil of cultivars ‘zard’, ‘roghani’, and ‘mari’ (from kazeroon region, located in fars province), were assessed. measurement of phenolic compounds showed that ‘mari’ cultivar oil contained the highest cinamic and vanilic acids with 1.4 and 1.18 milli...

To understand the resistance of the olive tree to the leaf-spot disease caused by Spilocaea oleagina, the constitutive and postinfectional synthesis phenolic compounds of the leaves were analyzed by HPLC in 110 genotypes F1 (susceptible cultivar “Picholine marocaine” x resistant cultivar “Picholine du Languedoc”) presenting of the differential behaviours to this disease (highly resistant, resis...

Over recent years, several studies have related olive oil ingestion to a low incidence of several diseases, including breast cancer. Hydroxytyrosol and tyrosol are two of the major phenols present in virgin olive oils. Despite the fact that they have been linked to cancer prevention, there is no evidence that clarifies their effect in human breast tumor and non-tumor cells. In the present work,...