Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of Alzheimer’s disease (AD). Previous studies suggested that coculture human MSCs with AD in an vitro model reduced expression amyloid-beta 42 (A?42) medium well overexpression amyloid-beta- (A?-) degrading enzymes such neprilysin (NEP). We focused on role primed (human Wharton’s jelly-derived mesenchymal (WJ-MSCs)...

Tumoral calcinosis is a rare benign disease entity that mimics a neoplasm and is manifested by calcium deposition in the soft tissues around the large joints. It can be primary or secondary to renal failure and hyperparathyroidism. This is, to our knowledge, the first reported case of tumoral calcinosis in a Hispanic male with rheumatoid arthritis.

Abstract Background Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the effect human serum-free medium (SF-MSCs) on fibrosis with that 10% fetal bovine (10%MSCs). Methods Peritoneal was induced by intraperitoneally injecting 0.1% chlorhexid...

Mesenchymal stromal cells (MSC) are used for cell-based treatment canine osteoarthritis (OA). Compared with human MSCs, detailed information on the functional characterisation of MSCs is limited. In particular, chondrogenic differentiation adipose tissue-derived (cAT-MSCs) challenging. this study, we aimed to compare cAT-MSCs bone marrow-derived (cBM-MSCs), focusing specifically their in vitro ...

Atopic dermatitis (AD) is a chronic cutaneous inflammatory disease caused by an interaction between genetic, immune and epidermal barrier factors. Several treatments can be used to treat this but there are patients that do not respond actual drugs. So, need develop effective therapies for AD. Mesenchymal stem cells (MSCs) non-hematopoietic multipotent adult progenitor with immunomodulatory powe...

Living therapeutics approaches that exploit mesenchymal stem cells (MSCs) as nanomedicine carriers are highly attractive due to MSCs native tropism toward the 3D tumor microenvironment. However, a streamlined pre-clinical evaluation of nano-in-cell anti-cancer therapies remains limited by lack in vitro testing platforms for screening MSCs-3D microtumor interactions. Herein we generated dense br...

Objective(s):Immunosuppressive property of mesenchymal stem cells (MSCs) has great attraction in regenerative medicine especially when dealing with tissue damage involving immune reactions. The most attractive tissue sources of human MSCs used in clinical applications are bone marrow (BM), adipose tissue (AT), and Wharton's jelly (WJ) of human umbilical cord. The current study has compared immu...

Introduction: Mesenchymal stem cells (MSCs) hold great promise in the field of regenerative medicine.Although originally isolated from bone marrow, MSCs have since been obtained from a variety of adult and neonatal tissues including the adipose tissue. Stemness and multipotential features of Mesenchymal Stem Cells (MSC) has been highlighted in many studies but there are many dark aspects in ex...