background: infl ammatory cytokines such as interleukin-6 (il-6) and tumor necrosis factor-alpha (tnf-α) are elevated in end-stage renal disease (esrd). il-6 and tnf-α are toxins which deteriorate renal function, and their pathogenic role has been confi rmed in cardiovascular and oral diseases. this study was designed to investigate the salivary levels of il-6 and tnf-α in patients with esrd un...

Background: Concentration of tumor necrosis factor alpha (TNF-alpha) might be useful in selecting patients with paroxysmal atrial fibrillation (PAF) who will benefit the most from pulmonary vein isolation.

background: tumor necrosis factor alpha (tnf-α) is a primary mediator of immune regulation and might be required in the early stages of dc development from cd34+ cells. however, details of optimal timing of exposure to tnf-α in dc development process in monocytes or non-purified hematopoitic cells are still lacking and clear benefits of this approach to the development of dcs remain to be valid...

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which plays crucial roles in pathogenesis of inflammatory diseases. The current study aimed to investigate the binding abilities of I44 and I49 domain antibodies to TNF-α. The dAbs were expressed in bacterial expression system and purified by affinity chromatography using Ni-sepharose column. The expression and purity of the protei...

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine which plays crucial roles in pathogenesis of inflammatory diseases. The current study aimed to investigate the binding abilities of I44 and I49 domain antibodies to TNF-α. The dAbs were expressed in bacterial expression system and purified by affinity chromatography using Ni-sepharose column. The expression and purity of the protei...

BACKGROUND Rats subjected to bile duct ligation (BDL) exhibit increased systemic oxidative stress and brain dysfunction characteristic of hepatic encephalopathy (HE), including fatigue, neurotransmitter alterations, cognitive and motor impairment, and brain inflammation. The levels of tumor necrosis factor-alpha (TNF-α) and asymmetric dimethylarginine (ADMA) are both increased in plasma and bra...

results there was no difference found between the two groups with regard to; gender, basic variables, ejection fraction (ef), cbp time and aortic cross-clamp time. the preoperative levels of il-6 and tnf-α were not different; however, their postoperative levels were significantly higher in the placebo group (p value = 0.01 for il-6 and 0.005 for tnf-α). conclusions this study showed that mgso4 ...

Background: Type 1 diabetes mellitus (T1DM) is a chronic, immune-mediated disease characterized by the destruction of insulin-producing β cells in pancreas. This study investigated influence single nucleotide polymorphisms (SNP) tumor necrosis factor (TNF-α) –308 G/A (rs1800629,) on T1DM patients. Method: The was included 75 patients and 25 healthy subjects. SNP–308 TNF-α gene detected using po...

Tumor necrosis factor alpha (TNF-α) a cytokine has been shown to be the key player during the pathogenesis of several autoimmune inflammatory disorders (presumably sterile inflammation) including rheumatoid arthritis (RA). Several studies have shown that TNF-α is mainly involved in the proinflammatory responses. However recent studies have reported multifunctional role of TNF-α during the devel...