objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. aggressive periodontitis (agp) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune res...

objective(s) using herbal medicines as a complementary treatment method is increasing in wide variety of diseases. ms14-an herbal-marine preparation-is reported to have anti-inflammatory and immunomodulatory activities; however, the mechanism underlying its therapeutic effect is not known. macrophages play an important role in host defense mechanisms and carry out their role by producing variou...

background: despite the outbreak in dental science, oral and dental complications in alzheimer are of the unsolved problems. it is assumed that tumor necrosis factor-α, which is a key factor in alzheimer, has a relation with periodontal complications in patients with alzheimer disease. the present study evaluated the effect of chronic periodontitis on serum levels of tumor necrosis factor-α in ...

background: s-methyl cysteine (smc) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. the purpose of the present study was to investigate the protective effect of smc on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome. methods: male wistar rats were divided into five groups (6 rats in each group), namely; control, con...

Background: Concentration of tumor necrosis factor alpha (TNF-alpha) might be useful in selecting patients with paroxysmal atrial fibrillation (PAF) who will benefit the most from pulmonary vein isolation.

Tumor necrosis factor-alpha is a critical pro-inflammatory cytokine produced by macrophages and was once considered an anti-tumor agent. However, a low dose of tumor necrosis factor-alpha can cause epithelial mesenchymal transition, angiogenesis and metastasis. NF-κΒ contributes to epithelial mesenchymal transition induced by tumor necrosis factor-alpha. Kanglaite, an extract from the Coix lacr...