PURPOSE Defining an adequate resection margin of colorectal cancer liver metastases is essential for optimizing surgical technique. We have attempted to evaluate the resection margin through a combination of histopathologic and genetic analyses. EXPERIMENTAL DESIGN We evaluated 88 samples of tumor margins from 12 patients with metastatic colon cancer who each underwent partial hepatectomy of ...

Introduction Astrocytic brain tumors – Gliomas in particular – are the most common brain tumors in adults. These malignant neoplasms are characterized by heterogeneous tissue with no distinct differentiation to healthy tissue because of their infiltrative growth. Therefore, the ratio of tumor cells versus healthy tissue in the tumor margin needs to be determined very precisely when the decision...

To determine the optimal treatment margin of local ablation therapy for small hepatocellular carcinoma (HCC), we investigated characteristics of microscopic satellite HCC nodules (msn) using resected livers, and the incidence of local recurrences in patients who underwent percutaneous microwave coagulation therapy (PMCT) according to whether or not an adequate treatment margin was achieved. We ...

BACKGROUND Non-melanoma skin cancer (NMSC) is the most common malignancy in the United States. Recommended treatment for NMSC remains surgical excision following a positive biopsy. Evidence of complete spontaneous regression of residual NMSC exists in the case of small lesions macroscopically removed by shave biopsy, but with a positive microscopic margin. The present study investigates the rat...

In radiotherapy, the constant margin taken around the visible tumor is a very coarse approximation of the invasion margin of cancerous cells. In this article, a new formulation to estimate the invasion margin of a tumor by extrapolating low tumor densities in magnetic resonance images (MRIs) is proposed. The current imaging techniques are able to show parts of the tumor where cancerous cells ar...

Objectives: To determine the predictive risk factors for isolated locoregional recurrence (LRR) in breast cancer patients with postmastectomy adjuvant therapy. Patients and Methods: The impacts of patients’ characteristics, tumor stage, and surgery on LRR were evaluated in patients with breast cancer having postmastectomy adjuvant therapy, according to their risk factors using univariate analys...

Aim: One of the most important factors associated with recurrence rate and overall survival is the status of surgical margin of resection free of disease. However, sometimes, the margins measured intra-operatively at the time of surgery differ of those measured by the pathologist in the histopathologic analysis. Faced with this dilemma, a literature review of the best available evidence was con...

Surgical margin status at prostatectomy is an important predictor of biochemical recurrence (BCR). The current convention is to categorize a margin as negative if tumor cells are not at the inked margin, even if they are within a few cells of the margin. We hypothesized that cancer within 0.1 mm of the margin conferred an increased risk for BCR. We determined the risk for BCR on the bass of sur...

BACKGROUND To dosimetrically evaluate the effect of reduced margin radiotherapy on hippocampal dose for glioblastoma multiforme (GBM) patients. METHODS GBM patients enrolled on the Radiation Therapy Oncology Group (RTOG) 0825 trial at our institution were identified. Standard RTOG 0825 expansions were 2 cm + 3-5 mm from the gross tumor volume (GTV) to the clinical tumor volume (CTV) and from ...

CONTEXT AND OBJECTIVE Cancer of the uterine cervix is still very common in Brazil. It is important to evaluate factors that influence its prognosis. The aim here was to analyze the prevalence of prognostic anatomoclinical factors among patients with carcinoma of the uterine cervix undergoing radical hysterectomy. DESIGN AND SETTING Cross-sectional study on 301 patients with invasive carcinoma...