BACKGROUND AND OBJECTIVE Uveal melanoma is the most common primary intraocular cancer; however, the molecular features that predict response to therapy are poorly understood. Our objective was to determine whether gene expression profiling (GEP) is associated with rate of tumor regression after I-125 plaque brachytherapy for uveal melanoma. PATIENTS AND METHODS Retrospective review of 138 pat...

MHC class II-restricted tumor Ags presented by class II(+) tumor cells identified to date are derived from proteins expressed in the cytoplasm or plasma membrane of tumor cells. It is unclear whether MHC class II(+) tumor cells present class II-restricted epitopes derived from other intracellular compartments, such as nuclei and/or mitochondria, and whether class II(+) tumor cells directly pres...

Non-classical class Ib (class Ib) genes are found in all jawed vertebrates, including the amphibian Xenopus, which possesses at least 20 distinct Xenopus non-classical class Ib genes (XNCs). As an immune evasion strategy, tumors often downregulate surface expression of classical major histocompatibility complex class Ia molecules. In contrast, cancers commonly express class Ib molecules, presen...

Tumor-derived exosomes (TEXs) are a class of extracellular vesicles which play an important role in the tumor microenvironment. These have multiple biological functions including promotion cancer progression and reduction anti-tumor immunity. Recently, interaction between TEXs immune cells great interest cell-based immunotherapy. Here, we review effects on survival T cell subsets, as well their...

conclusions pc-rplnd is one the major operations in the field of urology, which is associated with significant adjunctive surgeries. in appropriate cases, pc-rplnd was associated with good cancer specific survival in tertiary oncology center. results twenty-one patients underwent bilateral pc-rplnd. mean age was 26.3 years (ranged 16 - 47). mean size of retroperitoneal mass after chemotherapy w...

It is generally accepted that human and experimental tumor cells can lose major histocompatibility complex (MHC) class I molecules. These human leukocyte antigen (HLA) losses are detected when the primary tumor breaks the basal membrane, invades the surrounding tissues, and starts to metastasize. These altered HLA class I phenotypes probably constitute the major tumor escape mechanism facing an...

Cancer is the one of most prevalent and leading causes of death in the world. Current ad­vancements in technology improve the understanding of the pathogenesis and pathology of cancers. But, due to enlarging mortality rates, poor prognosis, and lacunae in clinical early predictive biomarkers provide an important momentum to investigate novel early diagnos­tic/prognostic markers and spec...

Downregulation of major histocompatibility complex (MHC) class I expression is an important mechanism by which tumors evade classical T cell-dependent immune responses. Therefore, a system was designed to evaluate parameters for active immunization against MHC class I- tumors. Mice were capable of rejecting a MHC class I- tumor challenge after immunization with an irradiated granulocyte/macroph...

The role of tumor-specific CD8 and CD4 lymphocytes in rejecting solid tumors has been difficult to determine because of the lack of models in which tumor antigen, specific CD8 cells, and specific CD4 cells can be monitored and controlled. To investigate the minimal components required for the induction and maintenance of CTL activity sufficient to reject a solid tumor in vivo, we transfected th...