background: chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. in vitro studies have been shown that arteether (are) induces apoptosis in tumor cells, but not in normal cells. objective: to investigate the cytotoxic and immunomodulatory properties of arteether in-vivo and in-vitro. methods: in this study, we ...

background: proliferation and expansion of cancer stem cells as spheroids were proved in previous studies. but, capability of primary tumor-derived stem cells to keep their unique properties in vitro is still disputed. so, the goal of this study was to isolate, expand and characterize of colon cancer-derived stem cells. material and methods: in the present work, colon cancer stem cells markers ...

In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...

Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro. Methods: In this study, we ...

t regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. t regulatory cells are produced in the thymus as a functionally mature subpopulation of t cells. they can be induced from naive t cells in the periphery and express their marker as a forkhead/winged helix transcription factor called fo...

Background: Alteration in peripheral blood lymphocytes (PBLs) is usually investigated to provide an evidence of the host immune responses to tumor antigens. The tumor infiltrating NK cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. Objective: To analyze peripheral blood and tumor associated Natural Killer (NK) cells in patients with breast ca...

littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. this report describes a case of littoral cell angioma with no malignant histological features. the lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. immunohistochemically, the...

objective: the present study examines the effects of increased heat shock proteins expression in mda-mb468 adeno-carcinoma cells on expansion and differentiation of hematopoetic stem cells from human umbilical cord blood. materials and methods: highly purified human cd34+ cells (magnetic bead isolation) derived from umbilical cord blood were cultured, under three conditions, in the presence of ...

introduction: the aim of this study was to investigate the effect of the hsp-70 (heat shock protein-70) induction in the lysate of heat shocked tumor cells on splenocyte proliferation, nitric oxide production by peritoneal macrophages, and fibrosarcoma tumor size reduction in balb/c mice. material and methods: wehi 164 cells (mouse fibrosarcoma cell line) were injected subcutaneously into the r...

background: overexpression of rad51 protein in many tumor cells has been proven to increase radioresistance and can be related to the resistance of chemosensitivity of tumor cells. this preliminary study was conducted to determine the relationship between the rad51 expression level in nasopharyngeal carcinoma and the response of the treatment based on the measurement of the tumor reduction. met...