Macrophages highly populate tumour microenvironment and are referred to as tumor-associated macrophages (TAMs). The inflammasome is a multiprotein complex responsible of IL-1 like cytokines release, which biology has been widely studied by using bone-marrow-derived macrophages to mimic a physiological and/or host defense condition. To understand the role of this complex in lung tumor-associated...

Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth in human malignancies. Published studies have analyzed the relationship between TAM infiltration and the prognosis of patients for many human tumors. Most studies reported a positive correlation between TAM density and a poor prognosis. Studies focusing on macrophage phenotypes emphasized the protumor role of M2 anti-inflam...

Macrophages in the tumor microenvironment engulf apoptotic cells through myeloid-epithelial-reproductive tyrosine kinase (MerTK)-mediated efferocytosis, and further polarized towards an M2 phenotype. However, regulatory mechanism of efferocytosis polarization tumor-associated macrophages (TAMs) remains unclear. Here, we performed single-cell RNA sequencing patients with melanoma identified a po...

As the most numerous inflammatory cell group in tumor microenvironment, tumor-associated macrophages (TAMs) have an essential effect therapy and are potential therapeutic targets. M2 type (M2-TAMs) were involved entire process of development, invasion, metastasis, obstructing anti-tumor chemotherapy drugs nano-medicine. This study aimed to construct a mannose modified co-loaded zoledronic acid ...

Tumor-associated macrophages (TAMs) and cyclooxygenase-2 (COX-2) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human basal cell carcinoma (BCC) remains elusive. We found that the number of TAMs infiltrating the tumor is correlated with the depth of invasion, microvessel density, and COX-2 expression in human BCC cells. TAMs al...

Abstract Macrophages are plastic cells of innate immune system with diverse functions in tissue homeostasis. Despite their abundance the tumor microenvironment (TME), tumor-associated macrophages (TAMs) and regulation mechanisms remain largely unknown. also key players metabolic processes including lipid metabolism. As TME has been known as a “lipid-rich” environment, we interested understandin...

Abstract Macrophages are critical mediators of tissue homeostasis, cell proliferation, and tumor metastasis. Tumor-associated macrophages (TAM) generally associated with tumor-promoting immunosuppressive functions in solid tumors. Here, we examined the transcriptional landscape adaptor molecules downstream Toll-like receptors human cancers found that higher expression MYD88 correlated progressi...

Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis, and recurrence after treatment. Macrophage plasticity and diversity allow their classification along a M1-M2 polarization axis. Tumor-associated macrophages usually display a M2-like phenotype, associated with pro-tumoral features whereas M1 macrophages exert antitumor functions. Targeting the reprogrammin...

Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment of many solid tumors. The functional competence of TAMs varies depending on the type of tumors and their respective microenvironments. The classically activated M1 macrophages exhibit antitumor functions, whereas the alternatively activated M2 macrophages exhibit protumor functions that contribute t...

Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor progression; however, the underlying guidance mechanisms are unknown. Here, we report that hypoxia-induced Semaphorin 3A (Sema3A) acts as an attractant for TAMs by triggering vascular endothelial growth factor receptor 1 phosphorylation through the associated holoreceptor, composed of Neuropilin-1 (Nrp1) and ...