A large proportion of tuber culin tests in tropical countries yield weak or doubtful reactions. Since leprosy is common in many of the countries where this phenomenon has been observed, it has been suggested that some of these anomalous r eactions may be due to nonspecific sensitization to mycobacterial antigens common to both the leprosy and the tubercle bacilli, The positive tuberculin hemagg...

Lymphocytes from uninfected, nonimmune mice can be stimulated to proliferate and produce antibody to diverse antigens in culture when exposed to the purified protein derivative of tuberculin or unheated tuberculin culture filtrate. Lymphocytes from numerous inbred strains of mice respond to tuberculin, but no true low responder strain has been found as yet. The evidence presented suggests that ...

FEMALE GUINEA PIGS WERE SUBJECTED TO LAPAROTOMY AT DIFFERENT STAGES OF PREGNANCY, AND THEIR FETUSES INJECTED THROUGH THE UTERINE WALLS WITH ONE OF THE FOLLOWING PREPARATIONS: Old Tuberculin, tubercle bacilli of the BCG strain killed by heat or exposure to phenol, and living BCG. A large number of the animals injected in utero with Old Tuberculin failed to develop skin hypersensitivity to P.P.D....

The aim was to study the tuberculin skin test in relation to immunological in vitro reactions in bacille Calmette-Guerin (BCG)-vaccinated healthcare workers. The present study was performed in Sweden, a country with a low incidence of tuberculosis, a high BCG vaccination efficacy and high tuberculin conversion rates. BCG-vaccinated healthcare workers (n=381) were tuberculin skin tested. From th...

Abstract Background Bovine tuberculosis (bTB), is a worldwide disease caused by Mycobacterium bovis ( M. ). The success of bTB eradication and control programs based on early detection the removal reactors from herd thus routine testing cull strategy have been applied globally. Since late nineteenth century, Tuberculin Skin Test (TST) has primary antemortem test available to support campaigns. ...