A meta-analysis of studies investigating the diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) for antibodies against tissue transglutaminases (tTG) of various origins in celiac disease (CD) diagnosis was carried out. Twenty-one studies, with untreated CD patients and healthy/CD-free controls, were included in the meta-analysis. The diagnostic accuracy was estimated using a summ...

X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the Bruton tyrosine kinase (Btk) gene. In order to identify the mutations in Btk gene in Iranian patients with antibody deficiency, 13 male patients with an XLA phenotype from 11 unrelated families were enrolled as the subjects of investigation for Btk mutation analysis using PCR-SSCP followed by sequencing. Five di...

x-linked agammaglobulinemia (xla) is an immunodeficiency caused by mutations in the bruton tyrosine kinase (btk) gene. in order to identify the mutations in btk gene in iranian patients with antibody deficiency, 13 male patients with an xla phenotype from 11 unrelated families were enrolled as the subjects of investigation for btk mutation analysis using pcr-sscp followed by sequencing. five di...

Objectives: Patellofemoral dislocation, the most severe presentation on spectrum of patellar instability, is common in adolescent populations. Trochlear dysplasia an integral component disorder, and procedures aimed at correcting instability by addressing this are often necessary. A theoretical risk injury to distal femoral physis exists these surgeries. At our institution, a thick-flap sulcus ...

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Objectives: Habitual and fixed patellar dislocations represent extreme forms of instability can lead to significant functional loss. The underlying complex pathoanatomy a laterally positioned shortened extensor mechanism pose challenges in its management. first purpose the study was evaluate presence these anatomic risk factors habitual dislocations. Conservative treatment options including bra...

•Cryo-EM structure of Cas12f in complex with a guide RNA and its target DNA•Type V-F effector consisting dimer single RNA•Molecular mechanism the RNA-guided DNA cleavage by miniature Cas12f•Evolutionary insights into possible origin type V CRISPR-Cas enzymes endonucleases derived from adaptive immune systems are widely used as powerful genome-engineering tools. Among diverse nucleases, (also kn...