This article discusses a rule-based fuzzy model for the identi cation of nonlinear MISO (multiple input, single output) systems. The dis cussed method of fuzzy modeling consists of two parts: structure modeling, i.e. determing the num ber of rules and input variables involved respec tively, and parameter optimization, i.e. optimizing the location and form of the curves which describe the fuz...

The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although molecular mechanisms explaining the development of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknown, we recently demonstrated that SSc patients overexpress CD19, an important regulatory molecule ...

The tight-skin (TSK/+) mouse, a genetic model of systemic sclerosis (SSc), develops cutaneous fibrosis and defects in pulmonary architecture. Because hepatocyte growth factor (HGF) is an important mitogen and morphogen that contributes to the repair process after tissue injury, we investigated the role of HGF in cutaneous fibrosis and pulmonary architecture defects in SSc using TSK/+ mice. TSK/...

This article discusses a rule-based fuzzy model for the identiication of nonlinear MISO (multiple input, single output) systems. The diss cussed method of fuzzy modeling consists of two parts: structure modeling, i.e. determing the numm ber of rules and input variables involved respecc tively, and parameter optimization, i.e. optimizing the location and form of the curves which describe the fuz...

Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules. These and other connective tissue abnormalities have made Tskl + mice models for scleroderma, hereditary emphysema, and myocardial hypertrophy. Previously we localized Tsk to mouse chromosome 2 in a region syntenic with human chromosome 15. The ...

This paper presents a new method to control of robot manipulator in task space. In the proposed control method, a combination of feedback linearization, sliding mode control and first-order TSK fuzzy system has been utilized. In this method, the bounds of structural and non-structural uncertainties by using feedback linearization method are reduced and to overcome the remaining uncertainties, s...

BACKGROUNDCONTEXT The Tampa Scale for Kinesiophobia (TSK) is commonly used in clinical practice to quantify levels of pain-related fear of activity or re-injury in patients presenting with back pain. Patients with high levels of kinesiophobia are often considered at greater risk of developing long-term activity limitation and chronicity. There is, however, little evidence to support this assump...

The Tight Skin mouse is a genetically induced animal model of tissue fibrosis caused by a large in-frame mutation in the gene encoding fibrillin-1 (Fbn-1). We examined the influence of gender on the collagen content of tissues in C57BL/6J wild type (+/+) and mutant Tight Skin (Tsk/+) mice employing hydroxyproline assays. Tissue sections were stained with Masson's trichrome to identify collagen ...

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by oxidative stress, impaired vascular function, and attenuated angiogenesis. The tight-skin (Tsk(-/+)) mouse is a model of SSc that displays many of the cellular features of the clinical disease. We tested the hypotheses that abnormal fibrillin-1 expression and chronic phospholipid oxidation occur in Tsk(-/+) mi...