نتایج جستجو برای: trpv3

تعداد نتایج: 245  

2014
Irène Marics Pascale Malapert Ana Reynders Stéphane Gaillard Aziz Moqrich

The discovery of heat-sensitive Transient Receptor Potential Vanilloid ion channels (ThermoTRPVs) greatly advanced our molecular understanding of acute and injury-evoked heat temperature sensation. ThermoTRPV channels are activated by partially overlapping temperatures ranging from warm to supra-threshold noxious heat. TRPV1 is activated by noxious heat temperature whereas TRPV3 can be activate...

متن کامل
Journal: :The Journal of biological chemistry 2005
Man-Kyo Chung Ali D Güler Michael J Caterina

2-Aminoethyl diphenylborinate was recently identified as a chemical activator of TRPV1, TRPV2, and TRPV3, three heat-gated members of the transient receptor potential vanilloid (TRPV) ion channel subfamily. Here we demonstrated that two structurally related compounds, diphenylboronic anhydride (DPBA) and diphenyltetrahydrofuran (DPTHF), can also modulate the activity of these channels. DPBA act...

متن کامل
Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2016
Shaw-Wen Wu Jonathan E M Lindberg James H Peters

Primary vagal afferent neurons express a multitude of thermosensitive ion channels. Within this family of ion channels, the heat-sensitive capsaicin receptor (TRPV1) greatly influences vagal afferent signaling by determining the threshold for action-potential initiation at the peripheral endings, while controlling temperature-sensitive forms of glutamate release at central vagal terminals. Gene...

متن کامل
Journal: :Journal of cell science 2015
Sarah Karttunen Michael Duffield Nathan R Scrimgeour Lauren Squires Wai Li Lim Mark L Dallas Jason L Scragg Johana Chicher Keyur A Dave Murray L Whitelaw Chris Peers Jeffrey J Gorman Jonathan M Gleadle Grigori Y Rychkov Daniel J Peet

Factor inhibiting HIF (FIH, also known as HIF1AN) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing ankyrin repeat domains (ARDs) have been characterised as substrates of FIH, although there is little evidence for a functional consequence of hydroxylation on these substrates. This study demonstrates that the transient...

متن کامل
Journal: :Journal of Investigative Dermatology 2023

Transient receptor potential vanilloid 3 subtype (TRPV3) plays an important role in pruritus. From our previous work, chronic pruritus dominantly attenuated TRPV3 knockout mice (TRPV3 KO). We found functional coupled with protease-activated 2 (PAR2) keratinocytes inducing TSLP releasing atopic dermatitis (AD). With bioinformatics investigation, we that mast cells of KO infiltrated less the derm...

متن کامل
Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Susan M Huang Hyosang Lee Man-Kyo Chung Una Park Yin Yin Yu Heather B Bradshaw Pierre A Coulombe J Michael Walker Michael J Caterina

The ability to sense changes in the environment is essential for survival because it permits responses such as withdrawal from noxious stimuli and regulation of body temperature. Keratinocytes, which occupy much of the skin epidermis, are situated at the interface between the external environment and the body's internal milieu, and have long been appreciated for their barrier function against e...

متن کامل
Journal: :American journal of human genetics 2012
Zhimiao Lin Quan Chen Mingyang Lee Xu Cao Jie Zhang Donglai Ma Long Chen Xiaoping Hu Huijun Wang Xiaowen Wang Peng Zhang Xuanzhu Liu Liping Guan Yiquan Tang Haizhen Yang Ping Tu Dingfang Bu Xuejun Zhu KeWei Wang Ruoyu Li Yong Yang

Olmsted syndrome (OS) is a rare congenital disorder characterized by palmoplantar and periorificial keratoderma, alopecia in most cases, and severe itching. The genetic basis for OS remained unidentified. Using whole-exome sequencing of case-parents trios, we have identified a de novo missense mutation in TRPV3 that produces p.Gly573Ser in an individual with OS. Nucleotide sequencing of five ad...

متن کامل
Journal: :BMC Neurology 2007
Paul Facer Maria A Casula Graham D Smith Christopher D Benham Iain P Chessell Chas Bountra Marco Sinisi Rolfe Birch Praveen Anand

BACKGROUND Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM...

متن کامل
Journal: :The Journal of biological chemistry 2004
Hong-Zhen Hu Qihai Gu Chunbo Wang Craig K Colton Jisen Tang Mariko Kinoshita-Kawada Lu-Yuan Lee Jackie D Wood Michael X Zhu

The transient receptor potential (TRP) superfamily contains a large number of proteins encoding cation permeable channels that are further divided into TRPC (canonical), TRPM (melastatin), and TRPV (vanilloid) subfamilies. Among the six TRPV members, TRPV1, TRPV2, TRPV3, and TRPV4 form heat-activated cation channels, which serve diverse functions ranging from nociception to osmolality regulatio...

متن کامل
2012
Yang Zheng Wang

Intracellular proton‐mediated activation of TRPV3 channels accounts for exfoliation effect of alpha hydroxyl acids on keratinocytes Xu Cao, Fan Yang, Jie Zheng and KeWei Wang Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center; Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616; USA; Depa...

متن کامل

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->