National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus (MRSA) infections recommend targeting a vancomycin 24-h area under the concentration-time curve (AUC0-24)-to-MIC ratio of >400. The range of vancomycin trough concentrations that best predicts an AUC0-24 of >400 in neonates is not known. This understanding would help clarify target trough concentrations in ne...

To evaluate driving aptitude and traffic-relevant performance at peak and trough medication levels in opioid-dependent patients receiving maintenance therapy with either buprenorphine (mean: 13.4 mg) or methadone (52.7 mg) and a medication-free control group, the Addiction Clinic at Medical University Vienna conducted a prospective, open-label trial where 40 opioid-dependent patients maintained...

Background: Nowadays the main problem in transplantation is the complexity of host immune system protection against the immunological and destructive reactions of the transplanted organ. High serum level of the immunosuppressive drug may cause toxicity and low serum level leads to the rejection of the transplanted organ. Cyclosporine has been known as the most effective immunosuppressive drug. ...

The objective of this study is to understand how interactions with upper-tropospheric troughs affect the intensity of tropical cyclones. The study includes all named Atlantic tropical cyclones between 1985 and 1996. To minimize other factors affecting intensity change, times when storms are over subcritical sea surface temperatures (#268C) or near landfall are removed from the sample. A trough ...

clearance of vancomycin to the clearance of the gold standard glomerular filtration rate (GFR) marker inulin is 0.89 in normal volunteers at steady state with endogenous creatinine as a filtration marker the ratio is 0.79 [5] . Therefore, the vancomycin clearance is a better GFR marker than is the creatinine clearance. Thus the interpretation of trough levels needs to be based on the renal func...

The plasma peak, trough, and peak-trough concentrations of netilmicin given to preterm and term infants were measured after different regimens to determine which dosage would provide satisfactory peak and trough concentrations. In infants aged less than 7 days, dosage regimens of 3.0 or 2.5 mg/kg every 12 hours gave satisfactory peak levels (range 5.2-12.0 micrograms/ml) but troughs were above ...

A question remains among the scientific community in the context of tropical cyclone (TC) intensity prediction: will an approaching upper-tropospheric synoptic-scale trough produce intensification or decay of a given TC? Many observational studies and numerical modeling have documented TC-trough interaction. Hanley et al. (2001) introduced the “good trough/bad trough” terminology to sort trough...

OBJECTIVES The optimum trough concentration of voriconazole for clinical response and safety is controversial. The objective of this review was to determine the optimum trough concentration of voriconazole and evaluate its relationship with efficacy and safety. METHODS MEDLINE, EMBASE, ClinicalTrials.gov, the Cochrane Library and three Chinese literature databases were searched. Observational...

BACKGROUND Critical care patients are prone to venous thromboembolism (VTE) and, thus, pharmacological thromboprophylaxis is generally advised. Low-molecular weight heparins (LMWHs) have become the drug of choice in ICU patients, since their predictable and reproducible dose response. Monitoring their pharmacological effect is not usually necessary except in special occasions (i.e. with obese o...