SUMMARY OF BACKGROUND DATA The association between the facet tropism and the development of lumbar disc herniation has been studied; however the results remain controversial. OBJECTIVE To determine the association between the facet tropism and the development of lumbar disc herniation. STUDY DESIGN A cross-sectional study. MATERIAL AND METHOD MRI of 34 patients with lumbar disc herniation...

BACKGROUND geno2pheno[coreceptor] is a bioinformatic method for genotypic tropism determination (GTD) which has been extensively validated. OBJECTIVES GTD can be affected by sequencing/base-calling variability and unreliable representation of minority populations in Sanger bulk sequencing. This study aims at quantifying the robustness of geno2pheno[coreceptor] with respect to these issues. GT...

Acute kidney injury (AKI) is a common complication, affecting up to 37% of hospitalized patients with SARS-CoV-2 infection and proportional its severity portends poor prognosis. Diverse mechanisms have been proposed studies reported conflicting results. Moreover, renal tropism does not equate pathogenicity. For virus be pathogenic, in addition affinity (tropism) for specific tissue(s), host cel...

Investigation on the brain-tropism was carried out through direct injection of virus into vitreous body eye using five marine fish species: kelp grouper, striped jack, Japanese flounder, threeline grunt and yellow tail. When brains intravitreously-injected (106 TCID50 Fish-1) were examined at 72 h post infection, jack nervous necrosis (SJNNV; type species genus Betanodavirus) frequently detecte...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

Following extensive propagation in fibroblasts, human cytomegalovirus (HCMV) loses tropism for a number of otherwise natural host cells, in particular, endothelial cells. In this study, the hypothesis was tested that loss of endothelial tropism is associated with the appearance of genomic variants. Initial quantitative focus expansion assays on endothelial monolayers demonstrated that, while th...

BACKGROUND The use of CCR5 antagonists involves determination of HIV-1 tropism prior to initiation of treatment. HIV-1 tropism can be assessed either by phenotypic or genotypic methods. Genotypic methods are extensively used for tropism prediction. However, their validation in predicting tropism of viral isolates belonging to group M non-B subtypes remains challenging. In Cameroon, the genetic ...

BACKGROUND To determine if tropism for CXCR4 or CCR5 correlates with cellular HIV DNA load, residual viraemia and CD4 count in 219 successfully treated naive subjects with HIV infection enrolled in five infectious diseases units in Northeastern Italy. METHODS A subset of subjects, achieving plasma HIV RNA level <50 copies/ml after initiation of first-line therapy and maintaining it until foll...

BACKGROUND HIV-1 coreceptor tropism testing is used to evaluate eligibility for CCR5 antagonist therapy. However, HIV-1 RNA-based tests are not suitable for virologically suppressed patients, therefore the use of proviral DNA tropism testing has been investigated. We describe a novel proviral DNA-based genotypic tropism assay and compare its performance to that of a sensitive HIV-1 RNA-based ge...