The induction of apoptosis by 66 alkaloids of the quinoline, quinolizidine, pyrrolizidine, isoquinoline, indole, terpene, tropane, steroid, purine, and piperidine type, of 9 cardiac glycosides, 11 non-protein amino acids and 10 further secondary metabolites was assayed in HL-60 cell cultures and measured by quantification of the subdiploid DNA content by flow cytometry, detection of DNA fragmen...

The tropane and granatane alkaloids belong to the larger pyrroline and piperidine classes of plant alkaloids, respectively. Their core structures share common moieties and their scattered distribution among angiosperms suggest that their biosynthesis may share common ancestry in some orders, while they may be independently derived in others. Tropane and granatane alkaloid diversity arises from ...

background & aim: a. belladonna (family: solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. tropane alkaloids are distinct group of secondary metabolites of the ‎solanaceae family.  the most important alkaloids of a. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. therefore identification and ‎determi...

the solanaceae plants produce a variety of interesting biologically active products including the steroid alkaloids solanidine, nicotine and tropane alkaloids. putrescine n-methyltransferase (pmt) is an enzyme that catalyses s-adenosylmethionine-dependent methylation of putrescine in one of the primary steps of nicotine and tropane alkaloids biosynthesis pathway. two tobacco members of the ap2/...

Scopolia lurida, a native herbal plant species in Tibet, is one of the most effective producers of tropane alkaloids. However, the tropane alkaloid biosynthesis in this plant species of interest has yet to be studied at the molecular, biochemical, and biotechnological level. Here, we report on the isolation and characterization of a putative short chain dehydrogenase (SDR) gene. Sequence analys...

Four known tropane alkaloids were isolated from the leaves of the endemic Chilean plant Latua pubiflora (Solanaceae). For the first time; 3alpha-cinnamoyloxitropane and apoatropine are reported in this plant. Scopolamine and hyoscyamine were previously reported.

background and objectives: hyoscyamus reticulatus contains two distinguished tropane alkaloids, hyoscyamineand scopolamine and both of the compounds possesspotential acute or chronic toxicity. in the present study, a simple and efficient transformation system was established for in vitro hairy roots induction in hyoscyamus reticulatus. methods: effect of different factors including agrobacteriu...