نتایج جستجو برای: trkb

تعداد نتایج: 2355  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Kerstin W Sinkevicius Christina Kriegel Kelly J Bellaria Jaewon Lee Allison N Lau Kristen T Leeman Pengcheng Zhou Alexander M Beede Christine M Fillmore Deborah Caswell Juliana Barrios Kwok-Kin Wong Lynette M Sholl Thorsten M Schlaeger Roderick T Bronson Lucian R Chirieac Monte M Winslow Marcia C Haigis Carla F Kim

Lung cancer is notorious for its ability to metastasize, but the pathways regulating lung cancer metastasis are largely unknown. An in vitro system designed to discover factors critical for lung cancer cell migration identified brain-derived neurotrophic factor, which stimulates cell migration through activation of tropomyosin-related kinase B (TrkB; also called NTRK2). Knockdown of TrkB in hum...

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Journal: :Cancer research 2007
Thomas R Geiger Daniel S Peeper

Anoikis, or cell death induced by cell detachment, provides protection against the metastatic spread of tumor cells. We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic. Because TrkB is overexpressed in several aggressive human cancers, first attempts are being made ...

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2014
Agustin Anastasia Katrin Deinhardt Shiyang Wang Laura Martin Donna Nichol Krithi Irmady Jasmine Trinh Luis Parada Shahin Rafii Barbara L. Hempstead Pouneh Kermani

Pericyte and vascular smooth muscle cell (SMC) recruitment to the developing vasculature is an important step in blood vessel maturation. Brain-derived neurotrophic factor (BDNF), expressed by endothelial cells, activates the receptor tyrosine kinase TrkB to stabilize the cardiac microvasculature in the perinatal period. However, the effects of the BDNF/TrkB signaling on pericytes/SMCs and the ...

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2013
Wei Bao Haifeng Qiu Tingting Yang Xin Luo Huijuan Zhang Xiaoping Wan

Mechanisms governing the metastasis of endometrial carcinoma (EC) are poorly defined. Recent data support a role for the cell surface receptor tyrosine kinase TrkB in the progression of several human tumors. Here we present evidence for a direct role of TrkB in human EC. Immunohistochemical analysis revealed that TrkB and its secreted ligand, brain-derived neurotrophic factor (BDNF), are more h...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Xiao Ping He Enhui Pan Carla Sciarretta Liliana Minichiello James O McNamara

The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cgamma1 (PLCgamma1) signaling is the key pathway and tested this in trkB(PLC/PLC) mice carrying a mutation (Y816F) that uncouples TrkB from PLCgamma1. Biochemical measures revealed activation of both TrkB a...

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Journal: :Oncotarget 2015
Hong Jiang Shuhong Huang Xinyun Li Xian Li Shanying Huang Yun Zhang Zhe-Yu Chen

Tyrosine kinase receptor B (TrkB) is a high-affinity receptor for brain-derived neurotrophic factor (BDNF). In addition to its nervous system functions, TrkB is also expressed in the aortic endothelium. However, the effects of endothelial TrkB signaling on atherosclerosis remained unknown. Immunofluorescence analysis revealed that TrkB expression is downregulated in the endothelium of atheroscl...

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Journal: :Neuron 2000
Baoji Xu Keling Zang Naomi L Ruff Y.Alex Zhang Susan K McConnell Michael P Stryker Louis F Reichardt

To examine functions of TrkB in the adult CNS, TrkB has been removed from neurons expressing CaMKII, primarily pyramidal neurons, using Cre-mediated recombination. A floxed trkB allele was designed so that neurons lacking TrkB express tau-beta-galactosidase. Following trkB deletion in pyramidal cells, their dendritic arbors are altered, and cortical layers II/III and V are compressed, after whi...

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Journal: The Iranian Journal of Pharmaceutical Research 2010
CH Lai FX Zhang SK Lai YS Chan

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were sub...

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Journal: :Neuron 2004
Xiao-Ping He Robert Kotloski Serge Nef Bryan W Luikart Luis F Parada James O McNamara

Epileptogenesis is the process whereby a normal brain becomes epileptic. We hypothesized that the neurotrophin brain-derived neurotrophic factor (BDNF) activates its receptor, TrkB, in the hippocampus during epileptogenesis and that BDNF-mediated activation of TrkB is required for epileptogenesis. We tested these hypotheses in Synapsin-Cre conditional BDNF(-/-) and TrkB(-/-) mice using the kind...

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2011
Taishi Harada Yasushi Yatabe Masafumi Takeshita Takaomi Koga Tokujiro Yano Yisong Wang Giuseppe Giaccone

Purpose: TrkB has been involved in poor cancer outcome. TrkB mutations have been reported in non– small cell lung cancer. In this study, we aimed at characterizing the role of three potentially sensitizing TrkB mutations previously reported in lung cancer. Experimental Design: We characterized three activation loop mutants of TrkB (M713I, R715G, and R734C) in terms of pathway activation/phospho...

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