A new treatment strategy is needed, as the efficacy of triple therapy containing clarithromycin-the current standard treatment for Helicobacter pylori infection-is declining. Increasing antibiotic resistance of H. pylori is the most significant factor contributing to eradication failure. Thus, selecting the most appropriate regimen depending on resistance is optimal, but identifying resistance ...

BACKGROUND The aim of the present open-label, randomized control trial was to determine the clinical efficacy and safety of two 1-week bismuth-containing quadruple regimens and 1 levofloxacin-based triple regimen for the eradication of Helicobacter pylori infection in treatment-naive patients. The influence of susceptibility and host CYP2C19 polymorphisms on the efficacy was also evaluated. M...

INTRODUCTION This study aimed to compare the efficacy and safety of quadruple therapy containing doxycycline and routine quadruple therapy for Helicobacter (H.) pylori rescue eradication in patients who had failed the one-week triple therapy. METHODS Patients who failed the first-line eradication therapy were allocated into two groups. Group A patients (n = 43) were administered esomeprazole ...

BACKGROUND The success rates of therapies for treating Helicobacter pylori vary greatly worldwide and the ideal treatment has yet to be clearly established. AIMS A systematic review was carried out to evaluate the effectiveness of current first and second-line therapies in treating H.pylori infection. METHODS Two researchers independently carried out Internet search engine reviews (PUBMED, ...

background the use of quadruple therapy for helicobacter pylori ( h. pylori ) eradication is a highly efficacious, gold standard regimen. however, according to a num­ber of studies, this regimen has numerous compliance problems and adverse effects. in the current study we have evaluated the h. pylori eradication rate following a quadruple therapy that included omeprazole, bismuth subcitrate, am...

  Background: The effectiveness of classic standard triple therapy regimen of helicobacter pylori (H. pylori) eradication has decreased to unacceptably low levels, largely related to development of resistance to metronidazole and clarithromycin. Thus successful eradication of H. pylori infections remains challenging. Therefore alternative treatments with superior effectiveness and safety should...

BACKGROUND/AIMS Bismuth-containing quadruple and moxifloxacin-based triple regimens are recommended as second-line therapy for Helicobacter pylori infection. The aim of this study was to compare the efficacy of each regimen. METHODS From August 2004 to October 2012, a total of 949 patients (mean age, 54.32±12.08 years; male, 49.4%) who failed H. pylori eradication with a standard triple regim...

eradication rate of helicobacter pylori using low dose furazolidone in triple & quadruple therapies versus metronidazol in triple therapy in du patients

Helicobacter pylori infection is the most common infection worldwide and is associated with simple dyspepsia, heartburn and peptic ulcer diseases, most commonly leading to upper gastrointestinal bleeding and, ultimately, to the severe complication of gastric malignancy. Ninety percent of duodenal ulcers and 70% of gastric ulcers are associated with helicobacter pylori infections. Noninvasive me...

Helicobacter pylori (H. Pylori) is one of the most common infectious human pathogens. H. could induce inflammation, that causes illnesses and disorders upper gastrointestinal which including peptic ulcer diseases, dyspepsia, gastroesophageal reflux disease gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It important to use a better tolerated greatly effective eradication regimen. In ...