The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotype...

Aim: The present study was carried out with the objective to estimate the serum mineral status, and hormonal profile of goats in Kashmir valley. Materials and Methods: Thirty female goats (n=30) were selected randomly from three districts (ten from each district) of Kashmir valley. Serum minerals were estimated by atomic absorption spectrophotometry and hormones by 125 radioimmunoassay (RIA) te...

Retinoids are compounds with pleiotropic functions and a relatively selective targeting of certain skin structures. They are vitamins, because retinol (vitamin A) is not synthesized in the body and must be derived from diet, but also hormones with intracrine activity, because retinol is transformed into molecules that bind to nuclear receptors, exhibit their activity, and are subsequently inact...

Abstract: The thyroid involvement is very significant feature of fluorosis due to fluoride accumulation in soft tissues. The participation of long term consumption of fluoride in drinking water on thyroid hormone status and deiodinating enzymes in fluorotic patients selected randomly from various parts of fluoride endemic areas, was elucidated. Type I (D1) activity was depressed significantly (...

BACKGROUND Thyrotoxicosis is more frequent in postmenopausal women than in the general population, effectively accelerating bone turnover. Interleukin-6 has been shown to be involved in the pathogenesis of bone disorders. Thus, the aim of the present study was to assess the role of IL-6 and its soluble receptor in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in oestr...

1600 CMAJ, December 10, 2013, 185(18) © 2013 Canadian Medical Association or its licensors A46-year-old man with obesity, hypertension, hyperlipidemia and bipolar disorder presented with a rash (Figure 1) accompanied by ongoing excessive urine production, excessive thirst and blurred vision. The lesions had appeared on his arms 1 month earlier and had spread to his neck, buttocks and legs. He w...

Background: Since late 2019, the development of severe acute respiratory distress syndrome (SARS) occurred, which began as a small cluster cases in Wuhan, China and subsequently spread across globe shape global pandemic. Coronavirus disease 2019 (COVID-19) initiates an immune response over-activity leading to release pro-inflammatory cytokines, particularly interleukin-6 (IL-6), leads overt thy...

A new cellular model for the study of brown adipocyte development and differentiation in vitro is presented . Preadipocytes isolated from brown adipose tissue (BAT) of the djungarian dwarf hamster Phodopus sungorus are able to proliferate and differentiate in vitro into true brown adipocytes able to express the BAT marker protein the uncoupling protein (UCP) . Whereas basal UCP expression is ve...

PURPOSE The paper presents links between iodine provision and selected acute phase proteins' (APP) serum concentrations as well as their glycosylations profiles (investigated with the use of affinity immunoelectrophoresis with Concanavalin A as ligand) in children. MATERIAL AND METHOD 116 children (58 girls and 58 boys) were enrolled. Iodine level was measured in the morning (7:30-8:30) urine...

BACKGROUND & OBJECTIVES Heat stress related hyperthermia may cause damage to various organ systems. There are very few studies on the effects of hyperthermia on the endocrine system. We therefore, investigated effects of exogenously induced hyperthermia on adrenal, testicular and thyroid functions and behavioural alterations in pre-pubertal male Sprague-Dawley rats. METHODS Three groups of 30...