a simple and green synthesis of α-hydroxy phosphonates has been performed by reaction between aldehydes and triethyl phosphite using sodium dodecylphosphonate as anionic surfactant in micellar media under reflux conditions. the novel structures were recognized by 1h nmr, 13c nmr and 31p-nmr. the employ of green media, clean reaction profiles, simple experimental and work up procedures and high ...

The reaction of 3-mercapto-6-methyl-1, 2, 4-triazin-5 (2H)-one 1 with dimethyl 2a and trimethyl phosphite 3a at 100 C in absence of solvent yields the dimeric product 4 and while the alkylated products 5 and 6 are obtained for reaction with 3a. Methylation of 1 by methyl iodide gives alkylated product 5. Reaction of 1 with diethyl 2b and triethyl phosphite 3b by the same previous conditions yie...

A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in goo...

A one-pot synthetic strategy was developed for the synthesis of novel sulfamidophosphonates via a three-component Kabachnik-Fields reaction sulfanilamide, triethyl phosphite, and various aldehyde using ultrasound irradiation. Seven organophosphorus derivatives were synthesized with high yields through this newly method. The target compounds characterized by 1H, 31P, 13C NMR, IR. molecular struc...

An eco-friendly and one-step microwave-assisted green synthesis of new functionalized bisphosphonates derivatives was described by a three-component reaction aromatic sulfamide with triethyl orthoformate diethyl phosphite. The synthesized compounds were characterized 1H, 13C, 31P NMR IR analysis. Some these tested for in vitro anti-inflammatory activity showed moderate inhibition compared to di...

The reaction of diethyl phosphite with triethyl orthoformate and a primary amine followed by hydrolysis is presented, and the reaction was suitable for the preparation of (aminomethylene)bisphosphonates. 3-Amino-1,2,4-triazole was chosen as an interesting substrate for this reaction because it possesses multiple groups that can serve as the amino component in the reaction-namely, the side-chain...

The aim of this study was to investigate the sol gel synthesis of HA/FA nanoparticles and the possible formation of TCP phase or unstoichiometric calcium deficient hydroxyapatite (CDHA) from the precursors with a Ca/P ratio of 1.62. In order to prepare the sol, the solutions of Triethyl phosphite, ammonium fluoride and calcium nitrate in ethanol were used respectively as P, F and Ca precursors....

Hydrolytic reactions with the participation of water clusters are highly dependent on geometric shape reaction solution and its position in space. For example, hydrolysis triethyl phosphite acetonitrile occurs at different rates three 5-mm NMR tubes directed North-South, East-West Vertically, this difference can be very large. The rate ratios between vary greatly during day depending Sun sky. t...