INTRODUCTION We aimed to analyze the approaches to the diagnosis and treatment of patients with fascioliasis in light of current literature. METHODOLOGY Thirty-nine patients with fascioliasis admitted to the Surgery Clinic of Dicle Medical Faculty (Turkey) were included in this study. The demographic, clinical, diagnostic, treatment and outcome data were analyzed retrospectively. RESULTS Ab...

drought stress in plants, the change (increase or decrease) in the production of plant proteins. proteomics in recent years one of the most powerful tools that help us to study the changes in protein in order to investigate the proteome of wheat leaves in response to terminal drought, two genotypes susceptible and resistant wheat genotypes were evaluated under irrigated (non-stress) and rain-fe...

background: aspartate transaminase (ast) is an important enzyme in parasite and liver tissue. the purpose of this investigation is to evaluate triclabendazole (tcbz) effect on ast activity of fasciola gigantica parasite. to compare of enzyme level of parasite and its host tissue, enzyme activity of f. gigantica parasite and liver tissues were also determined. method: the livers were collected f...

hydatid disease is a term used to refer infection with the methacestode of echinococcus granulosus parasite in humans, and echinococcusis is restricted to infection with the adult stage in carnivores.glutathione s-transferase (gst) represents the major class of detoxification enzymes from helminth parasites such as echinococcus protoscoleces (psc) and it is candidate for chemotherapeutic and va...

proteomics refers to the analysis of expression, localization, functions, posttranslational modifications, and interactions of proteins expressed by a genome at a specific condition and at a specific time. current proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of proteome. in this review, we have focused on the proteom...

Fascioliasis, a zoonotic disease of domestic herbivorous animals such as sheep, cattle and goats, which are the definitive hosts, is caused by infection with the liver fluke, Fasciola hepatica. Humans become infected by eating uncooked, and usually unwashed, aquatic vegetables on which larval parasites are encysted. Although animals can support enormous worm burdens without developing serious d...

glutathione s-transferase (gst) represents the major class of detoxification enzymes from helminth parasites such as fasciola hepatica and f. gigantica and it is a candidate for chemotherapeutic and vaccine design. therefore, gst enzyme of fasciola spp. could be a target for evaluation of drugs such as triclabendazole (c14h9cl3n2os). for this purpose, gst enzymes were purified from fasciola spp...

background: fasciola hepatica is one of the most important helminthes parasites and triclabendazole (tcbz) is routinely used for treatment of infected people and animals. secreted protease enzymes by the f. hepatica plays a critical role in the inva-sion, migration, nutrition and the survival of parasite and are key targets for novel drugs and vaccines. the aim of study was to determine the pro...

introduction: to determine an indicator for triclabendazole (tcbz) efficacy, alanine aminotransferase (alt) activity in fasciola hepatica (iranian isolate) parasite in presence and absence of tcbz was evaluated by an in vitro cultivation method. also, alt enzyme activity between none and parasitized-infected sheep liver tissues was assessed. method:  the sheep livers were collected and transfer...

Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compa...