INTRODUCTION The purpose of this study was to elucidate the effects of histone deacetylase inhibition on the phenotype and function of dendritic cells and on arthritis in SKG mice. METHODS Arthritis was induced in SKG mice by zymosan A injection. Trichostatin A, a histone deacetylase inhibitor, was administered and its effects on arthritis were evaluated by joint swelling and histological eva...

Trichostatin A produces predominantly G(1) cell-cycle blockade and differentiation of the cisplatinum-sensitive A2780 ovarian cancer cell line. Given the propensity of ovarian tumors to become resistant to cisplatinum, often leading to cross-resistance to other agents, we have extended these observations by examining how the emergence of resistant phenotypes in A2780 cells affects the actions o...

Thymidylate synthase (TS) overexpression is a key determinant of 5-fluorouracil (5-FU) resistance in human cancer cells. TS is also acutely up-regulated with 5-FU treatment, and, thus, novel strategies targeting TS down-regulation seem to be promising in terms of modulating 5-FU resistance. Here, we report that histone deacetylase inhibitors can reverse 5-FU resistance by down-regulating TS. By...

background: epigenetic reprogramming of differentiated cells can modify somatic cells into pluripotential state. pluripotency can be induced in somatic cells by several approches. one of the easy ways to induce pluripotency is the exposure of the somatic cells to the embryonic stem cell (esc) extract. objective: the objective of this study was to increase the efficiency of reprogramming of gran...

To investigate the effect and mechanism of trichostatin A on bleomycin induced pulmonary fibrosis in mice compared with dexamethasone pirfenidone is objective study. C57 black 6 were instilled intranasal to establish model. They divided into five groups: Control group, model group group. Hematoxylin eosin staining Masson’s was conducted; expression related proteins each observed by immunohistoc...