During the past few years scattered information has appeared which indicates that at least some bacteria probably possess a tricarboxylic acid cycle. Lockwood and Stodola found that Pseudomonas jluorescens formed considerable quantities of a-ketoglutaric acid when growing on a glucose medium under conditions of intense aeration (1). Ajl and Werkman found evidence for at least parts of the conve...

During the past few years scattered information has appeared which indicates that at least some bacteria probably possess a tricarboxylic acid cycle. Lockwood and Stodola found that Pseudomonas jluorescens formed considerable quantities of a-ketoglutaric acid when growing on a glucose medium under conditions of intense aeration (1). Ajl and Werkman found evidence for at least parts of the conve...

Experimental studies of enzyme kinetics in vitro and metabolic fluxes in vivo have been used by Wright and her colleagues to develop a detailed kinetic model of the tricarboxylic acid cycle in Dictyostelium discoideum. This model has recently been been analyzed by two different methods (Albe, K. R., and Wright, B. E. (1992) J. Biol. Chem. 267, 3106-3114; Shiraishi, F., and Savageau, M. A. (199...

Previous papers from this laboratory (King and Cheldelin, 1952, 1952a, 1954; Hauge et al., 1955, 1955a) have reported on the oxidation of carbohydrates in Acetobacter suboxydans. Neither resting nor disintegrated cells can oxidize acetate or other intermediates of the tricarboxylic acid cycle. These findings have recently been confirmed in another laboratory (Rao and Gunsalus, 1955). From the c...

The oxidation of acetic acid in the dark by the non-sulfur purple bacterium, Rhodospirillum rubrum, was shown by van Niel (1, 2) to require the presence of either carbon dioxide or trace amounts of the Cb-dicarboxylic acids of the Krebs cycle. These results could readily be interpreted to mean that the oxidation of acetic acid proceeds by way of the Krebs cycle, the presence of COZ being requir...

Since the discovery of hydrothermal vents more than 25 years ago, the Calvin-Bassham-Benson (Calvin) cycle has been considered the principal carbon fixation pathway in this microbe-based ecosystem. However, on the basis of recent molecular data of cultured free-living and noncultured episymbiotic members of the epsilon subdivision of Proteobacteria and earlier carbon isotope data of primary con...