A series of 1,2,4-trisubstituted-1H- imidazole derivatives (4a-o) was synthesized by reacting 2,4-disubstituted-1H-imidazoles (3a-o) with chlorobenzene in the presence of triethylamine. Phenylglyoxal (2) was reacted with different aromatic aldehydes in the presence of ammonium acetate and glacial acetic acid to afford the disubstituted imidazoles (3a-o). The structures of the synthesized compou...

Syntheses of various classes of fused-imidazoles are reported. The key to their successful synthesis depends on the reaction of N-vinyl-1H-imidazole with the π-deficient compounds under basic conditions. Reaction of the target imidazole with 1,1,2,2-tetracyanoethylene and dimethyl acetylenedicarboxylate afforded pyrrolo[1,2-a]imidazoles. On the other site, reaction of the target imidazole with ...

This paper reports the synthesis of nitrogen containing heterocyclic compounds such as quinoxalines (5-7), imidazoles (8, 9,10,11), aminothiazole (12), aminooxazole (13), aminoimidazole (14) and benzothiazine (17) from the reaction with unsymmetrical diketone 4, 3 and 4a respectively. The aforementioned compounds with 4-pyridyl,4fluorophenyl groups have different positions in their ring skeleto...

The single crystal X-ray structure of the DMSO solvate of cyameluric acid C6N7O3H3 · 3DMSO, 2b’ has been determined. The results show that the most stable tautomer of solid cyameluric acid is the tri-keto form 2b with C3h symmetry. 1H and 13C NMR data indicate that this isomer is also present in solution, with slow interchange of the N-H protons. This confirms previous theoretical results altho...

Series of 4-arylimidazoles, omega-N-acylhistamines and 4-(omega-phenylalkyl)imidazoles were synthesized in order to probe the active site topology of sweet almond beta-glucosidase. These imidazole derivatives were shown to be very powerful competitive inhibitors. Among the 20 tested compounds, omega-N-benzoylhistamine and 4-(3'-phenylpropyl)imidazole are the most potent inhibitors of the enzyme...

Ceramides containing either sphingosine or sphinganine and one of the 2-hydroxy acids, 14h:0, 16h:0, 18h:0, 20h:0, 22h:0, 24h:0, and 26h:0 were prepared and separated by gas chromatography as the 1,3,2'-tri-O-tri-methylsilyl derivatives. Mass spectrometric analyses of these derivatives showed that the ions formed on electron impact can be used to determine unequivocally the structures of the lo...