The rhythmic motor pathway activation by pacemaker neurons or circuits in the brain has been proposed as the mechanism for the timing of motor coordination, and the abnormal potentiation of this mechanism may lead to a pathological tremor. Here, we show that the potentiation of Ca(V)3.1 T-type Ca(2+) channels in the inferior olive contributes to the onset of the tremor in a pharmacological mode...

High-frequency test stimulation for tremor suppression is a standard procedure for functional target localization during deep brain stimulation. This method does not work in cases where tremor vanishes intraoperatively, for example, due to general anaesthesia or due to an insertional effect. To overcome this difficulty, we developed a stimulation technique that effectively evokes tremor in a we...

S U M M A R Y Observations and theoretical considerations have cast doubt on the suggestion that volcanic tremor source processes may be modelled by a linear oscillator that is set into resonance by a sustained disturbance. Volcanic tremor signals that accompanied the 1996 Vatnajökull subglacial eruption, central Iceland, have been analysed using methods from the discipline of non-linear dynami...

Eye and body oscillations are shared features of several neurological diseases, yet their pathophysiology remains unclear. Recently, we published a report on two tennis players with a novel presentation of eye and body oscillations following self-administration of performance-enhancing substances. Opsoclonus/flutter and limb tremor were diagnosed in both patients. Common causes of opsoclonus/fl...

BACKGROUND Acquired generalized repetitive myoclonus may be mistaken for tremor. Distinguishing myoclonus has etiologic and therapeutic implications. OBJECTIVE To describe isolated generalized polymyoclonus and the outcomes of etiologic evaluations at the time of diagnosis. DESIGN Computer search of the Mayo Movement Neurophysiology Laboratory database and medical records linkage system. ...

Rebound burst activity can be generated in neurons in the subthalamic nucleus (STN) by strong GABAergic inhibitory inputs from the globus pallidus externa (GPe) that is reciprocally connected with the STN. It has been proposed that the rebound burst activity in STN neurons is a key event for generating synchronized rhythmic burst activity in the GPe-STN loop, which may be relevant to the restin...

http://dx.doi.org/10.1016/j.clinph.2016.12.014 1388-2457/Published by Elsevier Ireland Ltd on behalf of International Fe Opsoclonus and flutter are ocular oscillations consisting of continuous, involuntary, conjugate saccades without intersaccadic intervals. If these saccadic oscillations are purely horizontal, they are called ocular flutter; if they have horizontal, vertical and torsional comp...

background and purpose: multiple sclerosis (ms) is a chronic disease that gives rise to a number of unpleasant symptoms that can be difficult to manage by conventional means. there are some aspects of ms-related disability which can be improved by using deep brain stimulation (dbs); particularly movement disorders, such as tremor. the research aim is to study the effect of dbs on ms tremor with...

The origin of myoclonus in patients with complex regional pain syndrome (CRPS) is unknown. Eight patients with CRPS related myoclonus were clinically evaluated and studied with intermuscular and corticomuscular coherence analysis. Jerks were present at rest, aggravated during action and were frequently associated with tremulousness or dystonia. Electromyography demonstrated a burst duration ran...

Objectives We investigated the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA) and examined the pathophysiological role of neuronal activity of the Vim underlying ataxia. Methods Five patients with SCA with cortical atrophy (ages 60-69 years; 2 sporadic and three familial SCA) and five patients with ...