Recommendations for statin use for primary prevention of coronary heart disease (CHD) are based on estimation of the 10-year CHD risk. It is unclear which risk algorithm and guidelines should be used in European populations. Using data from a population-based study in Switzerland, we first assessed 10-year CHD risk and eligibility for statins in 5,683 women and men 35 to 75 years of age without...

OBJECTIVE To conduct a systematic review of rigorously evaluated treatments for infant colic. METHODS Online bibliographic databases were searched for the term "colic" in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses, and the selected articles were also reviewed for potential studies. The ab...

In one of our research group meetings, we took an informal poll to find out who would prescribe a benzodiazepine to someone who was acutely grieving, felt anxious, was experiencing some insomnia, and wanted relief from distress. The younger among us mostly would prescribe while those of us who are grizzled would mostly refrain from doing so. Coincidentally, within the next week, one of my patie...

The purpose of this article is to set forth our approach to diagnosing and managing the thalassemias, including -thalassemia intermedia and -thalassemia major. The article begins by briefly describing recent advances in our understanding of the pathophysiology of thalassemia. In the discussion on diagnosing the condition, we cover the development of improved diagnostic tools, including the use ...