Transitional immature B cells undergo apoptosis and fail to proliferate in response to BCR cross-linking, thus representing a target for negative selection of potentially autoreactive B cells in vivo. In agreement with recent reports, transitional B cells were divided into developmentally contiguous subsets based on their surface expression of CD23. When transferred, CD23(+) transitional B cell...

All transitional cell carcinomas of the bladder diagnosed in male patients within a five year period were studied for human chorionic gonadotropin (hCG) production. Biotin-avidin immunoperoxidase analysis for hCG was performed on all paraffin blocks containing carcinoma-in-situ, grade I, grade II, and grade III transitional cell carcinoma. Of a total of 29 patients, one case of carcinoma-in-sit...

opium use is one of the most common forms of substance abuse in iran and there are some evidence indicating it is a risk factor of transitional cell carcinoma (tcc) of the urinary bladder. the majority of opium users are also cigarette smokers, so consideration of the high prevalence of smoking which is the most important risk factor of tcc of the urinary bladder among opium users is essential ...

AIMS AND BACKGROUND Upper urinary tract transitional cell carcinoma, a relatively rare tumor, is up to 100 times more frequent in regions with Balkan endemic nephropathy. Characteristics of transitional cell carcinoma in the endemic South Morava Region in Serbia in the previous 50 years were evaluated. PATIENTS We analyzed 477 cases with pathologically confirmed transitional cell carcinoma wh...

The aim of this study was to evaluate the diagnostic value of AgNOR (Argyrophilic Nucleolar Organizer Proteins Region) staining in differentiation between malignant and non-malignant lesion, and histological grading of bladder transitional cell carcinoma. We have also showed the rate of AgNOR distribution score in the nuclear of malignant and non-neoplastic cells of bladder epithelium as an imp...

PURPOSE To compare the expression of survivin and its association with clinicopathological criteria in major types of urinary bladder carcinoma, specifically, transitional cell carcinoma with and without squamous differentiation and squamous cell carcinoma. MATERIALS AND METHODS Immunohistochemical staining for survivin and Ki67 was performed on paraffin-embedded sections of 104 carcinomas: 5...

A serum-free medium, DH-S1, is described which is valuable for the establishment of primary cultures of normal and malignant transitional epithelium (transitional cell carcinoma of the bladder). Growth of epithelial cells in DH-S1 is facilitated but that of fibroblasts is suppressed. Another established human transitional cell carcinoma cell line, 647V, has grown continually in DH-S1 for over 3...