introduction: anesthetic agents, blood pressure, arterial ph and blood gases have found to influence on the pathophysiology of experimental stroke. despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on ...

Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...

background: the role of renin angiotensin system (ras) in ischemic/reperfusion (i/r) injuries is not fully elucidated. furthermore, it is not clear whether inhibition of ras by angiotensin-converting enzyme (ace) inhibitors has beneficial effects in terms of protecting the brain from i/r injuries. in this study enalapril is used as an ace inhibitor to evaluate the role of ras in i/r injuries in...

Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders followin...

introduction: development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. blood brain barrier (bbb) opening is an important part of edema named as vasogenic brain edema. in this study, quantitative alterations of bbb permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. methods: two groups of male rats (ischemic and sh...

Recent evidence has shown crucial roles for cell-adhesion molecules in inflammation-induced rolling, adhesion, and accumulation of neutrophils in tissue. Intercellular adhesion molecule-1 (ICAM-1) is one of these adhesion molecules. Previous studies have shown marked reduction in the size of infarction after focal cerebral ischemia by depletion of granulocytes and administration of the antibody...

BACKGROUND The authors' previous study demonstrated that a clinical antiarrhythmic dose of lidocaine, when given before ischemia, is neuroprotective in a rat model of transient focal cerebral ischemia. In this study, the authors investigated whether the administration of this dose of lidocaine, when delayed until 45 min after the onset of ischemia, also reduces ischemic brain injury. METHODS ...

background: probiotics are microorganisms that may influence brain function via altering brain neurochemistry. new research evidence suggests that probiotic bacteria might protect tissue damage through diminishing the production of free radicals and/or inflammatory cytokines. therefore, this study was designed to evaluate the effects of probiotic bacteria on the prevention or reduction of brain...

objective(s): stroke poses a crucial risk for mortality and morbidity. our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. material and methods: rats were randomly divided into four groups, namely group i (control rats), group ii (ischemia rats), group iii (6 hr ischemia + p-coumaric acid rats) and group iv (24 hr ischemia + p-coumaric acid rats). ce...