Telomerase reverse transcriptase as the core component of telomere and most common non-coding region mutation gene in melanoma, may play a significant role development melanoma. The aim this study is to investigate anti-tumor effect human telomerase (hTERT) knockdown malignant melanoma its potential clinical value. We employed hTERT strategy detected expression target by transcriptase-quantitat...

INTRODUCTION Current Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two Nucleoside Reverse Transcriptase Inhibitors plus one boosted protease inhibitor (2NRTI+PI/r). Given the lower daily cost of NNRTI as the third a...

It is well established that the cytosine deaminase APOBEC3G can restrict HIV-1 virions in the absence of the virion infectivity factor (Vif) by inducing genome mutagenesis through deamination of cytosine to uracil in single-stranded HIV-1 (-)DNA. However, whether APOBEC3G is able to restrict HIV-1 using a deamination-independent mode remains an open question. In this report we use in vitro prim...