On the basis of biologically active 3-aminopyridine-2(1H)-ones, authors carried out chemical modification into derivatives corresponding monothiooxamides for first time. It has been shown that 3-aminopyridin-2(1H)-oneenter transamidation reactions with hydrazine-hydrate and are further cyclized under action chloroacetyl chloride conjugated 1,3,4-thiadizole derivatives.

In many organisms, the formation of asparaginyl-tRNA is not done by direct aminoacylation of tRNA(Asn) but by specific tRNA-dependent transamidation of aspartyl-tRNA(Asn). This transamidation pathway involves a nondiscriminating aspartyl-tRNA synthetase (AspRS) that charges both tRNA(Asp) and tRNA(Asn) with aspartic acid. Recently, it has been shown for the first time in an organism (Pseudomona...

Protein engineering of gluten, the exogenous effector in celiac disease, seeking its detoxification by selective chemical modification of toxic epitopes is a very attractive strategy and promising technology when compared to pharmacological treatment or genetic engineering of wheat. Here we present a simple and efficient chemo-enzymatic methodology that decreases celiac disease toxic epitopes o...

Previous publications from this laboratory (l-3) have described the catalysis of transamidation reactions by the proteinases papain, ficin, and crystalline chymotrypsin. In addition, preliminary experiments were reported on replacement reactions catalyzed by beef spleen cathepsin C, an intracellular endopeptidase of animal tissues, which resembles pancreatic chymotrypsin in its specificity. The...

Vitrimers are polymeric materials that behave as thermosets at room temperature but, when heated, they exhibit a plastic flow similar to thermoplastics, enabling their reprocessability. A series of new bio-based polyamide-polyamine vitrimers synthetized starting from tris(2-aminoethyl)amine and epoxidized methyl oleate, material can be easily prepared renewable resources obtainable both natural...

A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.