Opinions in the literature on the relationship between cannabis and aggression. violence and crime are varied and contradictory. Laboratory studies of the acute effects of cannabis on human beings indicate that aggression and violence, at least under controlled conditions, are rare. Most investigators report a quieting or tranquilizing effect, although significant changes in behaviour are ordin...

July, 1974 377 TERIAL blood gases and p11 may reflect the respiratory depression produced by tranquilizing and narcoticanalgesic agents used in premedication before surgical anesthesia. The absence of respiratory depression is one of the desirable qualities of an ideal premedicant or sedative drug. Therefore, it is essential to know if, and to what extent, a particular drug depresses respiratio...

Sleep disorder is a state of sleep loss caused by various reasons, which leads to a series of changes, such as emotion, learning and memory, and immune function. "Tranquilizing and allaying excitement" was widely used in clinical treatment of insomnia; however, the mechanism was still not very clear. We randomly divided rats into three groups: control group, sleep deprivation group, and acupunc...

Physiological studies and preliminary behavioral screening with animals have indicated that syrosingopinel (carbethoxysyringoyl methylreserpate) , a reserpine derivative, is a hypotensive drug with little or no “tranquilizing” action. The present study was designed to explore and check on these findings, as related to adverse behavioral effects, in a controlled experiment with human patients. T...

OBJECTIVE A national epidemiological survey in Chile assessed adaptive (health care utilization) and maladaptive (substance use) postearthquake behaviors. METHODS Three months after the 8.8-magnitude 2010 Bio-Bio earthquake, face-to-face interviews were conducted with a representative sample of 2,108 adults. Logistic regression analyses examined predictors of health care service utilization a...

OBJECTIVE Patients treated with antipsychotic drugs often receive concomitant psychotropic compounds. Few studies address this issue from a lifetime perspective. Here, an analysis is presented of the prescription pattern of such concomitant medication from the first contact with psychiatry until the last written note in the case history documents, in patients with a diagnosis of psychotic illne...

Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of sp...

The nonmedical use of scheduled medications commonly prescribed for pain, pain-related symptoms, and psychiatric disorders began rising in the mid-1990s. Physicians are confronted with the dilemma of how to minimize the abuse and diversion potential of these products without compromising access for patients with a legitimate medical need. Using data from the National Survey on Drug Use and Heal...

Experiments were carried on in the Wistar rats having self-stimulation (SS) electrodes implanted chronically in substantia nigra-ventral tegmental area (SN-VTA) to examine whether modulations of GABAergic, serotonergic, histaminergic, dopaminergic, and glucocorticoid neuronal receptor functions will affect or not the brain reward system and the SS behaviour. The modulators are the wellknown dru...

The present pharmacological study was conducted to investigate a possible role of the brain histaminergic system in vocalization induced in guinea pig pups by maternal separation and isolation in an unfamiliar environment. The effects of drugs acting at histamine receptors were determined after intraperitoneal injection, comprising hydroxyzine and chlorpheniramine, both histamine H1 antagonists...