Tranquilizer misuse represents a growing international public health problem with heavy social and economic consequences. We aimed to identify the psychosocial determinants of this practice, focusing on modifiable factors including knowledge attitudes towards these medications. A prospective cohort study involving 847 adults accompanying children in primary care clinics was carried out Spain. v...

Lippia alba (Mill.) N.E. Brown (Verbenaceae) is widely used in different regions of Central and South America as a tranquilizer. The plant's anxiolytic properties, however, merit investigation. The present study evaluated the effects of repeated daily (14 days) intraperitoneal (ip) treatment with an essential oil (EO) from a chemotype of L. alba (LA, chemotype II, 12.5 and 25 mg/kg; N = 6-8) an...

The kinetics of excretion of the novel tranquilizer cinazepam (3-hydroxy-7-bromo-5-(ortho-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one hemisuccinate (I)) in mice after a single administration and different schemes of multiple administration were determined. Mass balance was studied daily in excretions of mice (feces and urine) for 5-10 days. We observed that monoexponential renal excreti...

PURPOSE The purpose of this review was to systematically summarize research on nonmedical use of prescription medications (NMUPM) among U.S. adolescents, with specific focus on scheduled medications falling into one of the following drug classes: pain relievers, stimulants, sedatives, or tranquilizers. METHODS Databases were searched for peer-reviewed primary quantitative research published b...

OBJECTIVE There is a significant interindividual variability in treatment outcomes in methadone maintenance treatment (MMT) for opioid use disorder (OUD). This prospective cohort study examines the impact of comorbid psychiatric disorders on continued illicit opioid use in patients receiving MMT for OUD. METHODS Data were collected from 935 patients receiving MMT in outpatient clinics between...

Hop (Humulus ltrptttus L.) cones are uscd not only in brewing of beer but also in folk mcdicine as a tranquilizer or b{ttcr stornachic, In 1950s1960s, some papers reportcd the existence of substances which had estrogen like activity in hop cones,t-3} and Kumai and his colleagues discovered gonadotropin inhibitors containcd in hop cones.`) Unfortunately, the rcported bioactive substanccs have no...

Recent studies have demonstrated that psychotropic drugs such as reserpine and chlorpromazine cause a significant increase in plasma human prolactin (hPRL) levels, frequently inducing galactorrhea (Frantz et al., 1972). Chlorpromazine is now commonly used as a means of stimulating hPRL secretion in man (Friesen et al., 1972; Turkington, 1972). Borenstein et al. (1968) first reported that galact...