Newly synthesized 2-(2-((1H-indol-5yl)methylene)-hydrazinyl)-thiazole derivatives were evaluated for their in vitro cytotoxicity on two carcinoma cell lines A2780 and HeLa. Significant cytotoxic activity for 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-methylthiazole (1) and 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-phenylthiazole (3), on both A2780 [IC50: 11.6 μM (1), and 12.4 μM (3)] and H...

A simple spectrophotometric method for the determination of N-acetyl-L-cysteine (NAC) and N-(2-mercaptopropionyl)glycine (MPG) in pharmaceutical preparations was developed, validated, and used. The proposed equilibrium method is based on a coupled two-step redox and complexation reaction. In the first step, Fe(III) is reduced to Fe(II) by NAC or MPG. Subsequently, Fe(II) is complexed with 2,4,6...

Methods presently used for the determi­ nation of serum iron and unsaturated ironbinding capacity have somewhat limited spectrophotometric sensitivity. Since molar absorptivity of a metal-ligand complex is a relative measure of sensitivity, an increase in the former improves accuracy in the de­ termination of trace constituents, especially when they are abnormally low. Obviously, low amounts of...

An investigation was undertaken to study the factors which cause grossly elevated values in an automated procedure for chloride when the sample is contaminated with bromide. The questioned mercuric thiocyanate method of the autoanalyzer was compared to a similar system utilizing mercuric 2, 4, 6-tripyridyl-s-triazine as a substitute ligand source in the chloride exchange system. It was determin...

The Mn(II) ion in the title complex, [MnBr(2)(C(18)H(12)N(6))], is five-coordinated in a distorted square-pyramidal geometry by three N atoms of the tridentate 2,4,6-tri-2-pyridyl-1,3,5-triazine (tptz) ligand and two bromide anions. In the crystal, the pyridyl rings coordinated to the Mn atom are inclined slightly to their carrier triazine ring [dihedral angles = 8.0 (3) and 7.5 (3)°], whereas ...

The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid (1) and 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic (2) as well their derivatives 25 26 were carried out by substitution, hydrolysis demethylation reactions the corresponding four benzyl bromides. antioxidant potentials benzylic acid-derived bromophenols were, for first time, appraised several outstanding bioanalytic...

In the face of worsening malnutrition or undernutrition in poor countries, diversification food resources remains a high priority for World Health Organization (WHO). Thus, present study aims to determine phytochemical composition and antioxidant activity fat extracted from seeds Polyalthia longifolia angustifolia.
 The fatty acid profile oil, with hexane by Soxhlet method, was determined ...

A.CONSIDERABLE LITERATURE has developed with respect to the determination of vitamin E as total tocopherols. Several texts (1-3) present both chemical and biologic assay methods. Although the direct spectrophotometric determination of vitamin E in serum at its absorption peak of about 295 m is attractive, it is not practical because of very low sensitivity and the presence of many interfering s...