The relationship between amyloid and toxic species is a central problem since the discovery of amyloid structures in different diseases. Despite intensive efforts in the field, the deleterious species remains unknown at the molecular level. This may reflect the lack of any structure-toxicity study based on a genetic approach. Here we show that a structure-toxicity study without any biochemical ...

stachys lavandulifolia is used as the herbal tea and its wide and potent medical effects have been reported for the extract in animal studies. this study aimed to find the safety profile of the extract to find the appropriate doses for further human studies. the aerial parts of the plant were air-dried and the hydroalcoholic extract was obtained and concentrated by percolation method with 140 m...

The aim was to investigate interspecies relationships between body weight (W) (kg) and various pharmacokinetic parameters for the anti-tumor agents amsacrine and its 4-methyl-5-(N-methylcarboxamide) analogue, CI-921, and examine which pharmacokinetic parameter, if any, might be used to predict the toxicity of these agents. Pharmacokinetic, plasma protein binding, and toxicity data were availabl...

The relationship between aluminium toxicity and iron metabolism was studied. Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg body weight. After 45 days, aluminium intoxified rats had a significant loweredserum ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the serum ceruloplasmin level was elevated by 60%. This result shows t...

in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...