Abstract: The role of intracellular Ca2+ in CCl4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. Intracellular Ca 2+ responded to CCl4 intoxication with a biphasic increase. The first intracellular Ca 2+ peak increased up to 5.6-fold the control level at 1 hour, and the second Ca2+ peak 6.5-fold at 3.5 days...

placement of narcotics inside intestinal tract of passengers and their illegal transfer through police stations and customs is called body packer or body bagger syndrome.in other parts of the world transfer of cocaine by this method has been reported.this prospective study was done with the help of Anti-narcotic Agency on the transfer of opium and heroin packages from Fenruary 1996 to January 1...

Within the Predict-IV FP7 project a strategy for measurement of in vitro biokinetics was developed, requiring the characterization of the cellular model used, especially regarding biotransformation, which frequently depends on cytochrome P450 (CYP) activity. The extrahepatic in situ CYP-mediated metabolism is especially relevant in target organ toxicity. In this study, the constitutive mRNA lev...

BACKGROUND The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication, and the most common cause of death from paraquat poisoning is multiple organ failure (MOF). This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats. METHODS A total o...

background: methanol is a colorless and poisonous liquid that is commonly used as an industrial and household solvent. methanol poisoning is a rare but extremely hazardous form of in toxication that affects the central nervous system and causes visual disorder, drowsiness, seizures and coma.  case presentation: a 29-years-old man with methanol intoxication presented with drowsiness and acidosis...

Aliphatic cyclic tertiary amines constitute a major class of naturally occurring and synthetic drugs directed at central biogenic amine receptors. Microsomal metabolism of these amines is known to be associated with low levels of covalent binding and/or suicide inactivation of the pertinent metabolizing P-450 isozymes; two of the more notorious examples are phencyclidine (1-(1phenylcyclohexyl)p...

IL-1beta is a potent pro-inflammatory cytokine that regulates neuroinflammation during brain damage. The expression of IL-1beta has been reported to be elevated in the striatum and substantia nigra of patients with Parkinson's disease (PD). Moreover, greater prevalence of PD in men than in women is described previously. Here, by using a sensitive mice model in which the expression of luciferase...