Drug-induced toxic epidermal necrolysis (TEN) and acute cutaneous graft-versus-host reaction (GVHR) under immunopreventive therapy share some histopathological resemblance. So far, there are no serum biomarkers and no immunohistochemical criteria distinguishing with confidence and specificity the skin lesions of TEN and GVHR. Both diseases present as an inflammatory cell-poor necrotic reaction ...

Introduction Toxic Epidermal Necrolysis (TEN) is a rare and acute life threatening mucocutaneous reaction characterized by extensive necrosis and detachment of the epidermis, most commonly drug induced. Lenalidomide is a derivative of thalidomide used in treatment of multiple myeloma, myelodysplastic syndromes. We present a case of TEN in lenalidomide treated patient of multiple myeloma with HIV.

dehiscence. Closure is performed by tissue planes, with a V-Y suture. Close follow-up is required in the immediate postoperative period, with regular wound care. The cosmetic result of the double hatchet flap can be excellent, as tissue of similar characteristics is used, with preservation of hair, texture, and thickness,3 rapid healing, and minimal scarring and comorbidity. Possible complicati...

This syndrome was first described by Lyell (1956) in this country and by Lang and Walker (1956) in South Africa and has since been reported with increasing frequency. Beare (1962), in a comprehensive review, collected 35 cases from the published reports and described 10 further cases that he had observed personally. He suggests that it is unlikely that the syndrome could have been seen in the U...

Vancomycin is the most frequent trigger of drug-induced linear IgA bullous dermatosis. We describe a fulminant case of linear IgA bullous dermatosis in a 74-year-old man who experienced skin sloughing of 90% of his body surface after receiving vancomycin.

This chapter will summarize the historical development of geology and in particular the development of the modern uniformitarian view of the geological record and the millions-of-years time-scale. The important proponents of old-earth thinking (including Werner, Smith, Hutton, Cuvier, and Lyell) along with some of the opponents of this view as it was developing (the scriptural geologists) will ...